Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5183685..5184293 Replicon chromosome
Accession NZ_CP045552
Organism Pseudomonas aeruginosa strain YT12746

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag GEV42_RS24635 Protein ID WP_003123043.1
Coordinates 5183685..5184032 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag GEV42_RS24640 Protein ID WP_003114155.1
Coordinates 5184042..5184293 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEV42_RS24605 5179044..5179316 + 273 WP_021264275.1 cysteine-rich CWC family protein -
GEV42_RS24610 5179316..5180008 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
GEV42_RS24615 5180144..5181187 + 1044 WP_003134392.1 L,D-transpeptidase -
GEV42_RS24620 5181267..5182004 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
GEV42_RS24625 5182456..5183358 + 903 WP_003163340.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
GEV42_RS24635 5183685..5184032 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEV42_RS24640 5184042..5184293 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GEV42_RS24645 5184507..5185490 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
GEV42_RS24650 5185490..5186782 - 1293 WP_003123045.1 hypothetical protein -
GEV42_RS24655 5187041..5188301 - 1261 Protein_4878 hypothetical protein -
GEV42_RS24660 5188303..5188653 - 351 WP_003133726.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5183685..5200642 16957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T142120 WP_003123043.1 NZ_CP045552:c5184032-5183685 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T142120 NZ_CP060401:113267-113551 [Xenorhabdus nematophila]
ATGAAATCAGCACCAAAAAAATTTGATGTTGTGGAGTTTTTAGAAACAGAAGAAGATATTCAGGCATACTTAAATGCCGC
TATCGAAGAAAACGATACAAAATATTTATTTAAAGCATTAGGTAATATCGCCAGAAGAAAAAATATCAGCCAACTCTCGA
AAGAATCAGGAATAAGCCGAGAAGGGATATATAAGGCGTTATCCGGTGAAGGCAATCCATCGTTTAATACGGTATACAAA
ATATCGAAAGCACTGGGTTTGAAACTGCATTTTACGGGGGCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT142120 WP_003114155.1 NZ_CP045552:c5184293-5184042 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT142120 NZ_CP060401:112969-113256 [Xenorhabdus nematophila]
ATGATAACCATTGAAAGGACACAAAATTTTGAAAAATGGTTAAAATCCTTAAAAGACCGAATAGCAAAAGCCAAAATCTT
AATCAGAGTTGAAAGAATGGGAGAGGGCAATTTTGGTGATGTTGAATCGGTGGGAGGTGGAGTTTCGGAACTCAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTACTAACAAAAATAATGAAATCATATTATTACTCTGTGGCGGGGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCCAAACAACTCGCGAAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References