Detailed information of TA system TA142119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4837085..4838343
• Replicon: chromosome
• Accession: NZ_CP045552
• Organism: Pseudomonas aeruginosa strain YT12746

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: GEV42_RS22950
• Protein ID: WP_003112528.1
• Coordinates: 4837085..4837840 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: GEV42_RS22955
• Protein ID: WP_003086329.1
• Coordinates: 4837975..4838343 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEV42_RS22940	4832257..4834800	+	2544	WP_031630217.1	acyl-homoserine-lactone acylase QuiP	-
GEV42_RS22945	4834955..4836316	-	1362	WP_003120632.1	DNA recombination protein RmuC	-
GEV42_RS22950	4837085..4837840	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
GEV42_RS22955	4837975..4838343	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
GEV42_RS22960	4838416..4839702	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
GEV42_RS22965	4839758..4841347	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
GEV42_RS22970	4841426..4841902	+	477	WP_003112531.1	hypothetical protein	-
GEV42_RS22975	4841905..4842180	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T142119 WP_003112528.1 NZ_CP045552:c4837840-4837085 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T142119 NZ_CP060401:112969-113256 [Xenorhabdus nematophila]
ATGATAACCATTGAAAGGACACAAAATTTTGAAAAATGGTTAAAATCCTTAAAAGACCGAATAGCAAAAGCCAAAATCTT
AATCAGAGTTGAAAGAATGGGAGAGGGCAATTTTGGTGATGTTGAATCGGTGGGAGGTGGAGTTTCGGAACTCAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTACTAACAAAAATAATGAAATCATATTATTACTCTGTGGCGGGGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCCAAACAACTCGCGAAAGAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT142119 WP_003086329.1 NZ_CP045552:c4838343-4837975 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT142119 NZ_CP060401:113267-113551 [Xenorhabdus nematophila]
ATGAAATCAGCACCAAAAAAATTTGATGTTGTGGAGTTTTTAGAAACAGAAGAAGATATTCAGGCATACTTAAATGCCGC
TATCGAAGAAAACGATACAAAATATTTATTTAAAGCATTAGGTAATATCGCCAGAAGAAAAAATATCAGCCAACTCTCGA
AAGAATCAGGAATAAGCCGAGAAGGGATATATAAGGCGTTATCCGGTGAAGGCAATCCATCGTTTAATACGGTATACAAA
ATATCGAAAGCACTGGGTTTGAAACTGCATTTTACGGGGGCTTAA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7