Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3831322..3832543 Replicon chromosome
Accession NZ_CP045552
Organism Pseudomonas aeruginosa strain YT12746

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GEV42_RS18105 Protein ID WP_003162864.1
Coordinates 3831965..3832543 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GEV42_RS18100 Protein ID WP_003088112.1
Coordinates 3831322..3831876 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEV42_RS18075 3826890..3827441 + 552 WP_003102727.1 XRE family transcriptional regulator -
GEV42_RS18080 3827438..3827836 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
GEV42_RS18085 3827849..3828172 - 324 WP_003102734.1 multidrug efflux SMR transporter -
GEV42_RS18090 3828503..3828964 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
GEV42_RS18095 3828969..3831164 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
GEV42_RS18100 3831322..3831876 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
GEV42_RS18105 3831965..3832543 + 579 WP_003162864.1 HD domain-containing protein Toxin
GEV42_RS18110 3832651..3833838 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
GEV42_RS18115 3833828..3835999 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
GEV42_RS18120 3835989..3837266 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21911.78 Da        Isoelectric Point: 5.3655

>T142118 WP_003162864.1 NZ_CP045552:3831965-3832543 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDILRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T142118 NZ_CP060399:c5140233-5139952 [Xanthomonas hortorum pv. vitians]
ATGATAAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGTTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGTATTCCACCTGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGACGCGGGCAGTACAGCATCCGGATCAACGACCAGTGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGACATCGTCGATTACCACTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT142118 WP_003088112.1 NZ_CP045552:3831322-3831876 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT142118 NZ_CP060399:c5139934-5139644 [Xanthomonas hortorum pv. vitians]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATCCTGCTTGAGGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCCACCGCCGTGCCGCCGCGCCGCATCAACGAGATCGTGCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCCGCAGCGCTGGGCACGACCGAGCGCTTCTGGTTGGGCCTGCAGGCCGACTACGAGCTGGAAGAAGCG
CACCGCGCGCTGGGCGACCTGCCGTCACGGATCAAGCGGCTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References