Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2036127..2037635 Replicon chromosome
Accession NZ_CP045552
Organism Pseudomonas aeruginosa strain YT12746

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag GEV42_RS09465 Protein ID WP_003119682.1
Coordinates 2036127..2036714 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GEV42_RS09470 Protein ID WP_031671186.1
Coordinates 2036781..2037635 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEV42_RS09460 2032382..2035861 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
GEV42_RS09465 2036127..2036714 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
GEV42_RS09470 2036781..2037635 + 855 WP_031671186.1 AraC family transcriptional regulator Antitoxin
GEV42_RS09475 2037732..2039897 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
GEV42_RS09480 2040072..2041946 + 1875 WP_010793244.1 MFS transporter -
GEV42_RS09485 2042007..2042216 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T142116 WP_003119682.1 NZ_CP045552:2036127-2036714 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T142116 NZ_CP060399:c4776075-4775941 [Xanthomonas hortorum pv. vitians]
ATGAAGCGTGCAATTATACTGCTGGTGCTGTCGGTGTTTTCGGTCGGTATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
TGGCAAGGACGTGCAGGGCGCTGGCGAGAAAGTGGAAGACGCTGCGCGCAAGTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31901.23 Da        Isoelectric Point: 7.5295

>AT142116 WP_031671186.1 NZ_CP045552:2036781-2037635 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT142116 NZ_CP060399:c4776306-4776154 [Xanthomonas hortorum pv. vitians]
ATGAAGCGACTGCTGACACTGATGGTGCTAGGCCTGTTTTCGGCTGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
CGGCAAGGACATGCAGGGCGCAGGTGAGAAGGTCGAAAAGAAGGCCGATAATTGCAGCGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References