Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 716738..717141 Replicon chromosome
Accession NZ_CP045550
Organism Venatoribacter cucullus strain ASxS5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GAY96_RS03510 Protein ID WP_265574313.1
Coordinates 716738..716863 (-) Length 42 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GAY96_RS03515 Protein ID WP_265574314.1
Coordinates 716860..717141 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY96_RS03490 (GAY96_03445) 712960..713544 - 585 WP_228346129.1 phosphoheptose isomerase -
GAY96_RS03495 (GAY96_03450) 713594..713971 - 378 WP_228346130.1 YraN family protein -
GAY96_RS03500 (GAY96_03455) 714011..715783 - 1773 WP_265574311.1 penicillin-binding protein activator -
GAY96_RS03505 (GAY96_03460) 715818..716678 + 861 WP_265574312.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
GAY96_RS03510 (GAY96_03465) 716738..716863 - 126 WP_265574313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GAY96_RS03515 (GAY96_03470) 716860..717141 - 282 WP_265574314.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GAY96_RS03520 (GAY96_03475) 717371..717781 + 411 WP_265574315.1 MarR family transcriptional regulator -
GAY96_RS03525 (GAY96_03480) 717792..718712 + 921 WP_265574316.1 alpha/beta hydrolase -
GAY96_RS03535 (GAY96_03490) 719350..720231 - 882 WP_265574317.1 MBL fold metallo-hydrolase -
GAY96_RS03540 (GAY96_03495) 720377..721330 + 954 WP_265574318.1 helix-turn-helix domain-containing protein -
GAY96_RS03545 (GAY96_03500) 721433..722002 + 570 WP_228346136.1 alkylphosphonate utilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-37)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-74)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4412.08 Da        Isoelectric Point: 4.2289

>T142109 WP_265574313.1 NZ_CP045550:c716863-716738 [Venatoribacter cucullus]
MNIVWSPLALARVEDIAEYIAQDKPAAAAQWVDKLSAVTGV

Download         Length: 126 bp

>T142109 NZ_CP060398:c1497359-1497078 [Synechococcus sp. CBW1002]
ATGCCCTTTGAACTGGCGTTTCATCCCGAGGATCTGCGTGAATGGCGACAGCTGAGCGCGGGGATTCGCGAGCAGTTCAA
AAAGAAGCTGGCTGAGCGGCTGGTTGTCCCGCGAATTCCCGCCAGCAAGCTGCGGGACTCCAGTGATCGGTACAAGATCA
AGCTCCGCTCCGCCGGCTTCCGCCTGGTCTACGAGGTGCGTGACCACGAGGTGCTGGTGCTGGTTGTGGCGGTGGGCAAG
CGGGAGCGCAATGCTGTCTACCGCCAGGCCGATCAGCGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10796.44 Da        Isoelectric Point: 9.7284

>AT142109 WP_265574314.1 NZ_CP045550:c717141-716860 [Venatoribacter cucullus]
MSRVHLDEDIRPLSEFRAGIASFVKQIHDTRRPMVLTQRGRRVAVLVDVQEYERMKDRLELLEEIYKAEEQIASGAGVAH
QDTKARILNKLPR

Download         Length: 282 bp

>AT142109 NZ_CP060398:c1497603-1497349 [Synechococcus sp. CBW1002]
ATGGTCCACCGCGTTCTCGCTGAGACAGCAGTAAGCATCTCGGAGCACAAGAAAAACCCCATGGCCACCGTGGCAGCCGG
AGAGGGGATGGCCGTCGCAGTGCTGAACCGCAACGAGCCGGCCTTCTACTGCGTGCCGGCCAGGGCCTACGAAGAGCTGA
TGGATCTGGTGGACGACCTGGAGCTGGGTCGCCTCGCCGATGCCCGGCTGACGGACGGCCAGGAGCCGGTGCGGGTCAGC
CTCGATGCCCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References