Detailed information of TA system TA142107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 4155510..4156037
• Replicon: chromosome
• Accession: NZ_CP045547
• Organism: Streptomyces sp. SYP-A7193

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GEV49_RS18280
• Protein ID: WP_153178759.1
• Coordinates: 4155777..4156037 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GEV49_RS18275
• Protein ID: WP_153178758.1
• Coordinates: 4155510..4155767 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEV49_RS18255	4150835..4152613	-	1779	WP_153178755.1	polyamine aminopropyltransferase	-
GEV49_RS18260	4152712..4153248	-	537	WP_194279989.1	DUF2617 family protein	-
GEV49_RS39795	4153651..4153947	-	297	WP_165685312.1	hypothetical protein	-
GEV49_RS18270	4154153..4155346	+	1194	WP_153178757.1	pyridoxal phosphate-dependent aminotransferase	-
GEV49_RS18275	4155510..4155767	+	258	WP_153178758.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GEV49_RS18280	4155777..4156037	+	261	WP_153178759.1	Txe/YoeB family addiction module toxin	Toxin
GEV49_RS18285	4156429..4157874	-	1446	WP_153178760.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10339.75 Da
• Isoelectric Point: 9.4248

>T142107 WP_153178759.1 NZ_CP045547:4155777-4156037 [Streptomyces sp. SYP-A7193]
MKITFSSRAWEDYLWWQLQDRKILKRINTLITDIARNGNEGIGKPEPLKHGFQGYWSRRINDEHRLIYKATEDGVLIAQC
RYHYES

Nucleotide

• Length: 261 bp

>T142107 NZ_CP060398:c1213259-1212951 [Synechococcus sp. CBW1002]
ATGACAAAAACAATCACGACTATCTGGGACCCGGCCGCACACCTAACCACTGCCGATGATGTCGCGGCTTATTTGGAAGC
TGCGCTTCAAGATGGAGATCCTCAGCTTGTAGCCGCTGCTCTTGGCGATATTGCTAGGGCCAAAGGGATGAGCCAAATCG
CACGTGAGGCGGGTCTAGGCAGGGAGAGTCTGTACAAGTCCCTATCCTCTTCAGGAAATCCAGAATTAGCCACGGTATTG
AAGGTTATCTCGGCACTAGGCTTGCAACTACATGTCAGCGCTACTGACAATGCGAAAATGGCTGTCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9497.53 Da
• Isoelectric Point: 4.3246

>AT142107 WP_153178758.1 NZ_CP045547:4155510-4155767 [Streptomyces sp. SYP-A7193]
VKTMTYSESRARYAEVLNSVTDDREEVVITRAGHEPVVIVSLEDYESLKETAYLLRNPANARRLLASIDELENGGGTVRE
LATDE

Nucleotide

• Length: 258 bp

>AT142107 NZ_CP060398:c1213559-1213269 [Synechococcus sp. CBW1002]
ATGCTCGAGATCCGGGAGACGTCTGCCTATGCCGCGTGGTTTTCTTCCCTGCGTGACCGGACAGCCAAAGCTCGTATCGA
CATTCGCATCAGGCGTCTCTCCTTGGGCAACCCAGGCGACGTTCGCCCTGTAGGAGAGGGCGTATCAGAGCTAAGAATCC
ATTACGGCCCCGGCTATCGGATCTATCTGACAATGCAAGGAGAGGCCATCGTCATCCTTCTTGCAGGCGGGGACAAGAGC
TCTCAAGATCAGGATATTCGTCTCGCTAAGCATCTTGCTCGCAACCTCTAG