Detailed information of TA system TA142105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3691355..3692054
• Replicon: chromosome
• Accession: NZ_CP045538
• Organism: Proteus mirabilis strain CRE14IB

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: GD587_RS17135
• Protein ID: WP_004249093.1
• Coordinates: 3691355..3691741 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: GD587_RS17140
• Protein ID: WP_004246828.1
• Coordinates: 3691734..3692054 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD587_RS17120	3687374..3687955	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
GD587_RS17125	3688206..3689111	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
GD587_RS17130	3689121..3691193	+	2073	WP_004246830.1	glycine--tRNA ligase subunit beta	-
GD587_RS17135	3691355..3691741	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GD587_RS17140	3691734..3692054	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
GD587_RS17145	3692103..3692537	-	435	WP_036972158.1	hypothetical protein	-
GD587_RS17150	3692530..3693414	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
GD587_RS17155	3693632..3694918	-	1287	WP_049220287.1	DUF3748 domain-containing protein	-
GD587_RS17160	3695055..3695672	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
GD587_RS17165	3695974..3696597	+	624	WP_004246821.1	guanylate kinase	-
GD587_RS17170	3696652..3696927	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T142105 WP_004249093.1 NZ_CP045538:3691355-3691741 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T142105 NZ_CP060398:c1212815-1212558 [Synechococcus sp. CBW1002]
GTGCTGGGTGTAGTCGTGGTGCGAGCGAAGCTGGTCAAAATCGGCAACTCGAGAGGGATCCGCCTCGCCAAGCCACTGCT
TGAGGTTGCGGGGCTCGCTGACGAAGTCGAGATCGAAGCGGCTCCAGGGGTTCTGACCATCAGGCCATCCGCTCATCCGA
GGGCTGGCTGGGCAGAGGCGGCATCGTCTTTGGAGCCAGAGGGACTTCTGGATGAAATGAGCGCCACCCAGTTTGATGAC
GAAGAGTGGTCATGGTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT142105 WP_004246828.1 NZ_CP045538:3691734-3692054 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT142105 NZ_CP060398:c1212564-1212229 [Synechococcus sp. CBW1002]
ATGGTGACTGAAGAACACGTCTCAAGAGGCGATATCTTCCTTGTCGCGTTGAATCCCACGCGAGGATCTGAAATCAGGAA
GACGAGGCCTTGTGCCGTAGTGTCGCCGGACGAGCTTAATGCTCACCTTCGCACTTTCATTGTTGCGCCGCTCACAACTG
GCGGCCATCCATACCCATTTCGTGTGCGTTGCAGGTTTGATGGCAAGGACGGCCATGTTGTGGCTGATCAGCTGAGAGCT
GTAGACAGAGACCGTCTAGTCAAGCGGTTGGGGAGTCTGTCGGAGACTACGCTGAATGAACTGCTGAGTGTTCTTCAGGC
GATGTTCGCTGTGTAG

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97