Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2526709..2527390 Replicon chromosome
Accession NZ_CP045529
Organism Luteimicrobium xylanilyticum strain HY-24

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P9QBD7
Locus tag KDY119_RS11250 Protein ID WP_036949564.1
Coordinates 2526709..2527116 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5P9QBC5
Locus tag KDY119_RS11255 Protein ID WP_036949562.1
Coordinates 2527127..2527390 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDY119_RS11235 2521969..2522991 + 1023 WP_153022319.1 3-oxoacyl-ACP synthase III -
KDY119_RS11240 2523009..2525744 + 2736 WP_153022730.1 alpha/beta fold hydrolase -
KDY119_RS11245 2525699..2526718 + 1020 WP_153022729.1 NAD-dependent epimerase/dehydratase family protein -
KDY119_RS11250 2526709..2527116 - 408 WP_036949564.1 type II toxin-antitoxin system VapC family toxin Toxin
KDY119_RS11255 2527127..2527390 - 264 WP_036949562.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KDY119_RS11260 2527394..2528446 - 1053 WP_153022320.1 sigma-70 family RNA polymerase sigma factor -
KDY119_RS11265 2528577..2528978 + 402 WP_036949561.1 VOC family protein -
KDY119_RS11270 2528962..2529831 - 870 WP_036949560.1 HAD hydrolase family protein -
KDY119_RS11275 2530028..2530201 + 174 WP_083890785.1 CsbD family protein -
KDY119_RS11280 2530262..2531107 - 846 WP_036950592.1 ABC transporter ATP-binding protein -
KDY119_RS11285 2531115..2532161 - 1047 WP_153022321.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14391.46 Da        Isoelectric Point: 5.1456

>T142101 WP_036949564.1 NZ_CP045529:c2527116-2526709 [Luteimicrobium xylanilyticum]
VSVYVDTSAIVKLVVQERESRALTQWLTEAAPVVTSDLTRTELARAVRRVDTALAVRAQQVLDAFVVLGLTATVCDSAGR
LGPTTLRSLDAIHLASALQLGDELDALVTYDERLAAAAEAYGVVVVAPGVPHRQR

Download         Length: 408 bp

>T142101 NZ_CP060397:2779352-2779606 [Synechococcus sp. CBW1004]
ATGAAGCGGAAGAACCAGCGCACCCTTGAGCTGATCTTCTCCCGTCCCGCAAGCGGCAGCCTGCCGTGGAGGGACATCGA
GGCCCTGTTTCAGGAGCTTGGTGGGGATGTCAGTGAGAGGGCAGGCAGCCGAGTTGCGGTCGTTCTGTTTGGCGAAGTCA
GGGTCTTCCACAGGCCCCACCCATCGCCCGATACAGACAAGGGTGCTATTGCTTCGATCCGCAAATGGTTTCAAGAACAC
GGAGTGACACCATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9364.57 Da        Isoelectric Point: 6.3141

>AT142101 WP_036949562.1 NZ_CP045529:c2527390-2527127 [Luteimicrobium xylanilyticum]
MTTVGIRALKQNASAVIAQVERGETVTVTDRGRRVAQIVPLRSSLLDELVASGEARPARTDFRQLGLPSATGDLSGEILA
ARDDERY

Download         Length: 264 bp

>AT142101 NZ_CP060397:2779603-2779935 [Synechococcus sp. CBW1004]
ATGAATCTCATGAATGTGGATGGCTACCACGCCAAAATTGACTACGTCGAGGAGACGGATCAGTTCCGCGGGGAAATTCT
TGGGCTTTCTGGAGGGGCGGACTTTTATGGGGCCAGTCCTGAGGAGCTTCGCCGAGAATTCAAAAAGTCATTGGACGTCT
TTCTTGAGGTATGCAAGGAGCAAGGAATCGAGCCTCGTAGACACTATTCAGGCAAGTTCAATCTTCGGATTCCGCCTGAA
CTCCATGAGAAATTGGCGATGACTGCTGAGGCGCAGGGAAAGAGTCTCAATTCGCTTGCCCAGGAAGCACTTCAGAGAAG
TGTCTCAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P9QBD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5P9QBC5

References