Detailed information of TA system TA142099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 479432..480069
• Replicon: chromosome
• Accession: NZ_CP045529
• Organism: Luteimicrobium xylanilyticum strain HY-24

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KDY119_RS02120
• Protein ID: WP_036955012.1
• Coordinates: 479671..480069 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KDY119_RS02115
• Protein ID: WP_148284329.1
• Coordinates: 479432..479659 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KDY119_RS02090	474810..475841	-	1032	WP_083891215.1	ABC transporter ATP-binding protein	-
KDY119_RS02095	476007..476903	+	897	WP_153022652.1	alpha/beta hydrolase	-
KDY119_RS02100	476914..477699	+	786	WP_036954623.1	TSUP family transporter	-
KDY119_RS02105	477712..478467	-	756	WP_153021859.1	helix-turn-helix transcriptional regulator	-
KDY119_RS02110	478553..479350	+	798	WP_036954626.1	sulfite exporter TauE/SafE family protein	-
KDY119_RS02115	479432..479659	+	228	WP_148284329.1	antitoxin	Antitoxin
KDY119_RS02120	479671..480069	+	399	WP_036955012.1	PIN domain-containing protein	Toxin
KDY119_RS02125	480178..481497	+	1320	WP_153021860.1	aspartate kinase	-
KDY119_RS02130	481694..482779	+	1086	WP_153021861.1	aspartate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13889.73 Da
• Isoelectric Point: 4.8675

>T142099 WP_036955012.1 NZ_CP045529:479671-480069 [Luteimicrobium xylanilyticum]
MFVLDTDVVIDVLRSRSPLMLERFSEHGDALTVSAVTVAELHFGAARSSAPSSNRAAVEEFLAFLEVLPFDAAAAAHAGE
IRGALTAAGTPIGGYDVLIAGHARSVAAVLVTGNVREFSRVDGLRVVDWGDR

Nucleotide

• Length: 399 bp

>T142099 NZ_CP060397:c2303242-2302967 [Synechococcus sp. CBW1004]
ATGCAGGTTGTGAGTTTCTCCGAGGCTCGCGAGAGCTTCAAAACCGTTCTGGATCGCGTCGTCGCCGACGCCGATGTCAC
GTTGATCACCAGACGCCACGCCAAGGACGCGGTTGTGATGTCCCTCGACACTTATAACAGCCTGATGGAGACCGTGCATC
TGCTGCGTTCTCCCGCCAACGCAGCTCATCTGCAGCGCTCCCTGGAGCAGGCCGAACACGGTGAACTGCTGGAGCAGCCT
CTGTGGGAACCGGATCGCGCTGATGCCAACTGCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8699.78 Da
• Isoelectric Point: 6.2166

>AT142099 WP_148284329.1 NZ_CP045529:479432-479659 [Luteimicrobium xylanilyticum]
VTTTVFHSNRTQAVRLPKDVALPDDVREVEIVAVGDARVIVPARRRWEFWFAHGLEVSTDFMSHRDQPEAQERAW

Nucleotide

• Length: 228 bp

>AT142099 NZ_CP060397:c2302980-2302711 [Synechococcus sp. CBW1004]
ATGCCAACTGCTGAGCGCCTGGCCTGGACTCCGGCAGCCTGGGAGGATTACTTGTACTGGCAGGGTCAGGATCGCAAACA
GTTGCGTCGGATGTACCAGCTGATCCAGGCCTGCCTGCGGGAACCCTTCACAGGCATCGGCAAACCGGAGCCATTGCGTG
AAAATCTCTCCGGCTGCTGGTCCCGCCGGATTGATGACGAACACCGGCTTGTCTATCGCCTGGAAGCCTCACTGTTGGTG
ATCCTGGCCTGTCGCTACCACTACCGCTGA