Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3640672..3641323 Replicon chromosome
Accession NZ_CP045528
Organism Acinetobacter baumannii strain 6507

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag DLI71_RS17520 Protein ID WP_000838146.1
Coordinates 3640672..3640854 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag DLI71_RS17525 Protein ID WP_000966689.1
Coordinates 3640919..3641323 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLI71_RS17475 3635928..3636593 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
DLI71_RS17480 3636598..3636987 + 390 WP_032041498.1 hypothetical protein -
DLI71_RS17485 3636944..3637357 + 414 WP_001197735.1 hypothetical protein -
DLI71_RS17490 3637366..3637770 + 405 WP_000248324.1 hypothetical protein -
DLI71_RS17495 3637742..3638110 + 369 WP_000539752.1 hypothetical protein -
DLI71_RS17500 3638112..3638510 + 399 WP_001132270.1 hypothetical protein -
DLI71_RS17505 3638512..3638724 + 213 WP_000121166.1 hypothetical protein -
DLI71_RS17510 3638833..3639762 + 930 WP_000094300.1 hypothetical protein -
DLI71_RS17515 3639807..3640340 + 534 WP_001185622.1 hypothetical protein -
DLI71_RS17520 3640672..3640854 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
DLI71_RS17525 3640919..3641323 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DLI71_RS17530 3641419..3641937 + 519 WP_126784048.1 DUF4468 domain-containing protein -
DLI71_RS17535 3642034..3646002 + 3969 WP_000191303.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3611808..3661250 49442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T142098 WP_000838146.1 NZ_CP045528:3640672-3640854 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T142098 NZ_CP060397:c2302980-2302711 [Synechococcus sp. CBW1004]
ATGCCAACTGCTGAGCGCCTGGCCTGGACTCCGGCAGCCTGGGAGGATTACTTGTACTGGCAGGGTCAGGATCGCAAACA
GTTGCGTCGGATGTACCAGCTGATCCAGGCCTGCCTGCGGGAACCCTTCACAGGCATCGGCAAACCGGAGCCATTGCGTG
AAAATCTCTCCGGCTGCTGGTCCCGCCGGATTGATGACGAACACCGGCTTGTCTATCGCCTGGAAGCCTCACTGTTGGTG
ATCCTGGCCTGTCGCTACCACTACCGCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT142098 WP_000966689.1 NZ_CP045528:3640919-3641323 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT142098 NZ_CP060397:c2303242-2302967 [Synechococcus sp. CBW1004]
ATGCAGGTTGTGAGTTTCTCCGAGGCTCGCGAGAGCTTCAAAACCGTTCTGGATCGCGTCGTCGCCGACGCCGATGTCAC
GTTGATCACCAGACGCCACGCCAAGGACGCGGTTGTGATGTCCCTCGACACTTATAACAGCCTGATGGAGACCGTGCATC
TGCTGCGTTCTCCCGCCAACGCAGCTCATCTGCAGCGCTCCCTGGAGCAGGCCGAACACGGTGAACTGCTGGAGCAGCCT
CTGTGGGAACCGGATCGCGCTGATGCCAACTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References