Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3476510..3477007 Replicon chromosome
Accession NZ_CP045526
Organism Shigella sonnei strain 6607.69

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag GE169_RS17810 Protein ID WP_001173343.1
Coordinates 3476834..3477007 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag GE169_RS17805 Protein ID WP_000398619.1
Coordinates 3476510..3476806 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE169_RS17785 (3473241) 3473241..3473960 - 720 WP_000611285.1 two-component system response regulator DcuR -
GE169_RS17790 (3473957) 3473957..3475588 - 1632 WP_001216495.1 sensor histidine kinase -
GE169_RS17795 (3475769) 3475769..3475999 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
GE169_RS17800 (3476011) 3476011..3476283 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
GE169_RS17805 (3476510) 3476510..3476806 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
GE169_RS17810 (3476834) 3476834..3477007 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
GE169_RS17815 (3477126) 3477126..3478643 - 1518 WP_001295086.1 lysine--tRNA ligase -
GE169_RS17820 (3478880) 3478880..3480337 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
GE169_RS17825 (3480396) 3480396..3480653 - 258 Protein_3477 lysine decarboxylase LdcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T142090 WP_001173343.1 NZ_CP045526:3476834-3477007 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T142090 NZ_CP060396:c2757645-2757226 [Synechococcus sp. CBW1006]
ATGTACCTGATCGACACGATGGTGCTCTCTGAGCTGCGGCTGCGCCAGCGCGATCCAGGCGTGGTGGGGTGGATCAGCAA
CCAGCGGCAGGAGGATTGTTTTGTAAGCGTGGTGAGCATCGGCGAGATCGAGCGCGGCATCGCCCGCAAGCGTTCGAGCG
ATGCTGGTTTCGCCACGCAGCTGGCCGAATGGCTGGATCAGCTGTTGCGGCTGTATGGCGATCGGTTGCTGCCGGTGGAT
GTGGGGGTGGCGCGCCGCTGGGGGCTGCTCTCCGCTGAGATCGGCCATGACAGCGCCGATCTGCTGATTGCTGCCACGGC
ACTGGAGCGCGGCCTCACGGTGGTGACGCGCAACCTGCGGCATTTCGCGCCAACGGGGGTGCCGACCATGAACCCATGGA
GTGGGGAGGGCGGATCCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT142090 WP_000398619.1 NZ_CP045526:3476510-3476806 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT142090 NZ_CP060396:c2757896-2757636 [Synechococcus sp. CBW1006]
ATGGATGCCGTTTGGACCTTGCAGGACGCCAAAAATCGCTTCAGCGCCGTGGTGGATGCGGCGGCCCGGGGAGAACCCCA
GATGGTGACGCGCCGCGGCAAATGGGTGAGCGTGGTGCTCTCCGCAGAGGAGTACGAGCGGTTGCAGCGCCTCGAGCGGG
CCAGCGCGCCATCGCTTGCCGAGCTGCTGTTGCAGATGCCGCAAGACGACGAGCCCTTCGAACGGTTGCCCCTGACGCCA
AGGGAGTTCCCATGTACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References