Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2111495..2112149 Replicon chromosome
Accession NZ_CP045526
Organism Shigella sonnei strain 6607.69

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag GE169_RS11040 Protein ID WP_000244777.1
Coordinates 2111495..2111902 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag GE169_RS11045 Protein ID WP_000354046.1
Coordinates 2111883..2112149 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE169_RS11020 (2107452) 2107452..2109185 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
GE169_RS11025 (2109191) 2109191..2109901 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GE169_RS11030 (2109926) 2109926..2110822 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
GE169_RS11035 (2110934) 2110934..2111455 + 522 WP_001055874.1 flavodoxin FldB -
GE169_RS11040 (2111495) 2111495..2111902 - 408 WP_000244777.1 protein YgfX Toxin
GE169_RS11045 (2111883) 2111883..2112149 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
GE169_RS11050 (2112392) 2112392..2113372 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
GE169_RS11055 (2113568) 2113568..2114227 - 660 WP_000250274.1 hemolysin III family protein -
GE169_RS11060 (2114391) 2114391..2114702 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
GE169_RS11065 (2114747) 2114747..2116180 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
GE169_RS11070 (2116237) 2116237..2116980 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T142088 WP_000244777.1 NZ_CP045526:c2111902-2111495 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T142088 NZ_CP060396:2728202-2728600 [Synechococcus sp. CBW1006]
ATGGTGATCGACTCATCTGCAGTTCTGGCCATCCTGCAGAACGAACCGGAGCGCCACGCCTTCAACGAGGCCATCGCCGC
AGCAGAACAGTGCTCTCTCTCCTCTGCTTCCCTGGTGGAGCTCTCCATTGTGATGGAGGCACGCTTTGGTTCTGATGGGC
AGGGAGATCTTGATCTGTTTCTGAACACGGCTCTGATCGAAATCATCAGCCTGGATCGTGAACAGGCTGAACTCGCTCGC
GAGGCATTCAGTCGTTATGGCAAAGGACGTCATCGGGCTGGGCTGAACTTCGGCGATTGTTTTTCCTACGCCCTGGCCAA
GTGTCTCGCTGAACCGTTGCTGTTCAAAGGTGACGACTTCTGCCACACCGATCTCCAGCCCGCCTGCCCAGCGTCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT142088 WP_000354046.1 NZ_CP045526:c2112149-2111883 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142088 NZ_CP060396:2727933-2728202 [Synechococcus sp. CBW1006]
GTGGCCCTCAACATCCGCAACGCCGAGGCCAGCCGCCTCGCCGCTGAGGTGGCATCCCTCGCGGGCGAAACCAAAACCGC
CGCCGTGATCCTGGCCCTGAAAGAGCGTCTGCGGCGCCTGCAGCGCCAGAGCCACACCACAGCGAACAAGCAAGCCGCAC
TCGTCAACCGACTCGACCAGATCGCCCTACGTTGTGCTGGACGGCCGATCGGCGATCGTCGCAGCGCAGAAGAGATCCTC
GGCTACGACCCCATGGGCCTGCCCACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References