Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 522431..522915 | Replicon | chromosome |
| Accession | NZ_CP045526 | ||
| Organism | Shigella sonnei strain 6607.69 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A377EAU1 |
| Locus tag | GE169_RS02820 | Protein ID | WP_014334020.1 |
| Coordinates | 522431..522721 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A376K4R9 |
| Locus tag | GE169_RS02825 | Protein ID | WP_005142544.1 |
| Coordinates | 522721..522915 (-) | Length | 65 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE169_RS02785 (517502) | 517502..518116 | - | 615 | WP_000148710.1 | Tat proofreading chaperone DmsD | - |
| GE169_RS02790 (518159) | 518159..519013 | - | 855 | WP_000526502.1 | dimethyl sulfoxide reductase anchor subunit family protein | - |
| GE169_RS02795 (519015) | 519015..519632 | - | 618 | WP_000213029.1 | dimethylsulfoxide reductase subunit B | - |
| GE169_RS02800 (519643) | 519643..520719 | - | 1077 | Protein_551 | molybdopterin dinucleotide binding domain-containing protein | - |
| GE169_RS02805 (520792) | 520792..521474 | + | 683 | WP_254638643.1 | IS1-like element IS1A family transposase | - |
| GE169_RS02810 (521622) | 521622..521987 | - | 366 | WP_024174355.1 | hypothetical protein | - |
| GE169_RS02815 (521999) | 521999..522151 | - | 153 | WP_000379558.1 | DUF1391 family protein | - |
| GE169_RS02820 (522431) | 522431..522721 | - | 291 | WP_014334020.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GE169_RS02825 (522721) | 522721..522915 | - | 195 | WP_005142544.1 | hypothetical protein | Antitoxin |
| GE169_RS02830 (522935) | 522935..523420 | - | 486 | WP_053002468.1 | helix-turn-helix domain-containing protein | - |
| GE169_RS02835 (523547) | 523547..523810 | + | 264 | WP_001048456.1 | helix-turn-helix transcriptional regulator | - |
| GE169_RS02840 (523807) | 523807..524232 | + | 426 | WP_000693826.1 | toxin YdaT family protein | - |
| GE169_RS02845 (524304) | 524304..525368 | + | 1065 | WP_001262380.1 | hypothetical protein | - |
| GE169_RS02850 (525375) | 525375..526121 | + | 747 | WP_000788740.1 | ATP-binding protein | - |
| GE169_RS02855 (526143) | 526143..526868 | + | 726 | WP_000450631.1 | DUF1627 domain-containing protein | - |
| GE169_RS02860 (526884) | 526884..527306 | + | 423 | WP_001151171.1 | DUF977 family protein | - |
| GE169_RS02865 (527364) | 527364..527720 | + | 357 | WP_005140877.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 521622..546742 | 25120 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11062.93 Da Isoelectric Point: 10.2013
>T142084 WP_014334020.1 NZ_CP045526:c522721-522431 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
Download Length: 291 bp
>T142084 NZ_CP060396:886601-886858 [Synechococcus sp. CBW1006]
GTGCTGGGTGTAGTCGTGGTGCGAGCGAAGCTGGTCAAAATCGGCAACTCGAGAGGGATCCGCCTCGCCAAGCCACTGCT
TGAGGTTGCGGGGCTCGCTGACGAAGTCGAGATCGAAGCGGCTCCAGGGGTTCTGACCATCAGGCCATCCGCTCATCCGA
GGGCTGGCTGGGCAGAGGCGGCATCGTCTTTGGAGCCAGAGGGACTTCTGGATGAAATGAGCGCCACCCAGTTTGATGAC
GAAGAGTGGTCATGGTGA
GTGCTGGGTGTAGTCGTGGTGCGAGCGAAGCTGGTCAAAATCGGCAACTCGAGAGGGATCCGCCTCGCCAAGCCACTGCT
TGAGGTTGCGGGGCTCGCTGACGAAGTCGAGATCGAAGCGGCTCCAGGGGTTCTGACCATCAGGCCATCCGCTCATCCGA
GGGCTGGCTGGGCAGAGGCGGCATCGTCTTTGGAGCCAGAGGGACTTCTGGATGAAATGAGCGCCACCCAGTTTGATGAC
GAAGAGTGGTCATGGTGA
Antitoxin
Download Length: 65 a.a. Molecular weight: 7097.98 Da Isoelectric Point: 4.1759
>AT142084 WP_005142544.1 NZ_CP045526:c522915-522721 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
Download Length: 195 bp
>AT142084 NZ_CP060396:886157-886465 [Synechococcus sp. CBW1006]
ATGACAAAAACAATCACGACTATCTGGGACCCGGCCGCACACCTAACCACTGCCGATGATGTCGCGGCTTATTTGGAAGC
TGCGCTTCAAGATGGAGATCCTCAGCTTGTAGCCGCTGCTCTTGGCGATATTGCTAGGGCCAAAGGGATGAGCCAAATCG
CACGTGAGGCGGGTCTAGGCAGGGAGAGTCTGTACAAGTCCCTATCCTCTTCAGGAAATCCAGAATTAGCCACGGTATTG
AAGGTTATCTCGGCACTAGGCTTGCAACTACATGTCAGCGCTACTGACAATGCGAAAATGGCTGTCTAA
ATGACAAAAACAATCACGACTATCTGGGACCCGGCCGCACACCTAACCACTGCCGATGATGTCGCGGCTTATTTGGAAGC
TGCGCTTCAAGATGGAGATCCTCAGCTTGTAGCCGCTGCTCTTGGCGATATTGCTAGGGCCAAAGGGATGAGCCAAATCG
CACGTGAGGCGGGTCTAGGCAGGGAGAGTCTGTACAAGTCCCTATCCTCTTCAGGAAATCCAGAATTAGCCACGGTATTG
AAGGTTATCTCGGCACTAGGCTTGCAACTACATGTCAGCGCTACTGACAATGCGAAAATGGCTGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A377EAU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376K4R9 |