Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4298662..4299316 Replicon chromosome
Accession NZ_CP045524
Organism Shigella sonnei strain 6904.27

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag GE168_RS21645 Protein ID WP_000244777.1
Coordinates 4298909..4299316 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag GE168_RS21640 Protein ID WP_000354046.1
Coordinates 4298662..4298928 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE168_RS21615 (4293831) 4293831..4294574 + 744 WP_000951937.1 SDR family oxidoreductase -
GE168_RS21620 (4294631) 4294631..4296064 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
GE168_RS21625 (4296109) 4296109..4296420 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
GE168_RS21630 (4296584) 4296584..4297243 + 660 WP_000250274.1 hemolysin III family protein -
GE168_RS21635 (4297439) 4297439..4298419 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
GE168_RS21640 (4298662) 4298662..4298928 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
GE168_RS21645 (4298909) 4298909..4299316 + 408 WP_000244777.1 protein YgfX Toxin
GE168_RS21650 (4299356) 4299356..4299877 - 522 WP_001055874.1 flavodoxin FldB -
GE168_RS21655 (4299989) 4299989..4300885 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
GE168_RS21660 (4300910) 4300910..4301620 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GE168_RS21665 (4301626) 4301626..4303359 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T142070 WP_000244777.1 NZ_CP045524:4298909-4299316 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T142070 NZ_CP060395:1030561-1030959 [Synechococcus sp. CBW1108]
ATGCTCCGCTATCTGCTCGACACCAACATCTGCATTTACGTGATCAAGCGAAGGCCCCAGGAGCTTCTGAGCAGCTTCAA
TCGCCACGCCAGCCATATGGGAATCTCCACGATCACCCTGGCGGAACTGCTGCATGGCTGCGAAAAGAGCAGCGATCCCA
GCCGTAATCTGGCGGTTGTGGAGAACTTCTACAGCCGTCTCGAAGTGCTCGCCTATGGGCCAAAAGCGGCCCAGCACTAT
GGCCAGATCCGCACCGATCTGGAACGCAAAGGCCAACCCATCGGCGTTAACGATCTTCACATTGCGGCCCACGCCCGCAG
CGAAGGGCTCACCCTGGTGAGCAACAATCTGCGTGAGTTCAACCGGGTGCCGGGGCTGCTGGTGGAAAACTGGATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT142070 WP_000354046.1 NZ_CP045524:4298662-4298928 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142070 NZ_CP060395:1030316-1030552 [Synechococcus sp. CBW1108]
ATGGTGGCGGTCACCAAGCTCTTCCTCAGCAACCGCAGCCAGGCCGTGCGCATCCCGGCCCCGCTGCGCCTGCCGGATTC
CGTGACGGCCGTTGAAGTGCGCGCCTGCGGCCAGGAACGGATCATCGCCCCGGTGGGCAGCAGCTGGGACAGCTTTTTCC
GCGACGGCCCCACCGCCTCCGACGACTTTCTGGCTGAGCGCCCATCCCAGGGTCAAAGCGAGCGGGAATCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References