Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2936565..2937062 Replicon chromosome
Accession NZ_CP045524
Organism Shigella sonnei strain 6904.27

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag GE168_RS14895 Protein ID WP_001173343.1
Coordinates 2936565..2936738 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag GE168_RS14900 Protein ID WP_000398619.1
Coordinates 2936766..2937062 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE168_RS14875 (2931717) 2931717..2932873 + 1157 WP_112368105.1 IS3-like element IS600 family transposase -
GE168_RS14880 (2932919) 2932919..2933176 + 258 Protein_2910 lysine decarboxylase LdcC -
GE168_RS14885 (2933235) 2933235..2934692 + 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
GE168_RS14890 (2934929) 2934929..2936446 + 1518 Protein_2912 lysine--tRNA ligase -
GE168_RS14895 (2936565) 2936565..2936738 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
GE168_RS14900 (2936766) 2936766..2937062 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
GE168_RS14905 (2937289) 2937289..2937561 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
GE168_RS14910 (2937573) 2937573..2937803 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
GE168_RS14915 (2937984) 2937984..2939615 + 1632 WP_001216495.1 sensor histidine kinase -
GE168_RS14920 (2939612) 2939612..2940331 + 720 WP_000611285.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T142068 WP_001173343.1 NZ_CP045524:c2936738-2936565 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T142068 NZ_CP060395:c973160-972732 [Synechococcus sp. CBW1108]
GTGTGCGTTGACGTCAATGTGCTGGTGCAGGCCTGCCTGCAGATCTCGCCACGCCATCACGAGGCGCGTGCCTGGCTCTT
GGCGAATCGTGCCGTTCCGGAGGGTCTGGGCCTGTTCTCTGTGGTGGTGAGCGGCTTCCTGAGGGTGGCCACCGACCGGC
GCGTGTTCAGCGAACCCCTGGATGCGGCCGTCGCCATTGCCTTTATCGACAGCCTCACCGCTTCTCCGGCGGTGTCGATC
CTGGATCCAGGCCCCCGCCATTGGGACCTGTTCCGTCAGATGGTGCTTGACCATCGGCCCAGCTCTCAGGACATGACCGA
TGTGTACCTGGCAGCAGCAGCCCTGGAGATAGGCGCCACCTGGGTGTCCTTTGATCGGGGCTTTGCCCGCTTCAAAGGGT
TGCGCTGGCTGAATCCTGCTGATCTCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT142068 WP_000398619.1 NZ_CP045524:c2937062-2936766 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT142068 NZ_CP060395:c973429-973169 [Synechococcus sp. CBW1108]
ATGCGCACCACGCTCACCATCAGCGACGCTCTTTACGTGCAGGCCAAGCTGCAGGCTGCCCGGGAGGGCGCTTCGGTGGG
CGCGGTGTTCGAGGCGGCGCTGCAGGCCTATCTCGATCGAGCGCGTCAGCTGGCGCGGAGCGAGCTTCCTCCCCTGCCGG
TGCATGGGGGGGGTGTGCTGCGCCCAGGTGTTGATCTTGATGACATGTCGGCACTCCGCGCGTTGCTTGATGAGGGCCTG
CCGCTGGAGCAGCTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References