Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2936565..2937062 Replicon chromosome
Accession NZ_CP045524
Organism Shigella sonnei strain 6904.27

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag GE168_RS14895 Protein ID WP_001173343.1
Coordinates 2936565..2936738 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag GE168_RS14900 Protein ID WP_000398619.1
Coordinates 2936766..2937062 (-) Length 99 a.a.

Genomic Context

GE168_RS14875GE168_RS14880GE168_RS14885GE168_RS14890GE168_RS14915GE168_RS14920GE168_RS14895GE168_RS14900GE168_RS14905GE168_RS14910
Location: 2931717..2932873 (1157 bp)
Type: Others
Protein ID: WP_112368105.1
Location: 2932919..2933176 (258 bp)
Type: Others
Protein ID: Protein_2910
Location: 2933235..2934692 (1458 bp)
Type: Others
Protein ID: WP_000856831.1
Location: 2934929..2936446 (1518 bp)
Type: Others
Protein ID: Protein_2912
Location: 2937984..2939615 (1632 bp)
Type: Others
Protein ID: WP_001216495.1
Location: 2939612..2940331 (720 bp)
Type: Others
Protein ID: WP_000611285.1
Location: 2936565..2936738 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 2936766..2937062 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 2937289..2937561 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Location: 2937573..2937803 (231 bp)
Type: Others
Protein ID: WP_000371698.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GE168_RS14875 (2931717)2931717..2932873+1157WP_112368105.1IS3-like element IS600 family transposase-
GE168_RS14880 (2932919)2932919..2933176+258Protein_2910lysine decarboxylase LdcC-
GE168_RS14885 (2933235)2933235..2934692+1458WP_000856831.1dipeptide/tripeptide permease DtpC-
GE168_RS14890 (2934929)2934929..2936446+1518Protein_2912lysine--tRNA ligase-
GE168_RS14895 (2936565)2936565..2936738-174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
GE168_RS14900 (2936766)2936766..2937062-297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
GE168_RS14905 (2937289)2937289..2937561-273WP_000405647.1GNAT family N-acetyltransferase-
GE168_RS14910 (2937573)2937573..2937803-231WP_000371698.14Fe-4S mono-cluster protein YjdI-
GE168_RS14915 (2937984)2937984..2939615+1632WP_001216495.1sensor histidine kinase-
GE168_RS14920 (2939612)2939612..2940331+720WP_000611285.1two-component system response regulator DcuR-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T142068 WP_001173343.1 NZ_CP045524:c2936738-2936565 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T142068 NZ_CP060395:c973160-972732 [Synechococcus sp. CBW1108]
GTGTGCGTTGACGTCAATGTGCTGGTGCAGGCCTGCCTGCAGATCTCGCCACGCCATCACGAGGCGCGTGCCTGGCTCTT
GGCGAATCGTGCCGTTCCGGAGGGTCTGGGCCTGTTCTCTGTGGTGGTGAGCGGCTTCCTGAGGGTGGCCACCGACCGGC
GCGTGTTCAGCGAACCCCTGGATGCGGCCGTCGCCATTGCCTTTATCGACAGCCTCACCGCTTCTCCGGCGGTGTCGATC
CTGGATCCAGGCCCCCGCCATTGGGACCTGTTCCGTCAGATGGTGCTTGACCATCGGCCCAGCTCTCAGGACATGACCGA
TGTGTACCTGGCAGCAGCAGCCCTGGAGATAGGCGCCACCTGGGTGTCCTTTGATCGGGGCTTTGCCCGCTTCAAAGGGT
TGCGCTGGCTGAATCCTGCTGATCTCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT142068 WP_000398619.1 NZ_CP045524:c2937062-2936766 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT142068 NZ_CP060395:c973429-973169 [Synechococcus sp. CBW1108]
ATGCGCACCACGCTCACCATCAGCGACGCTCTTTACGTGCAGGCCAAGCTGCAGGCTGCCCGGGAGGGCGCTTCGGTGGG
CGCGGTGTTCGAGGCGGCGCTGCAGGCCTATCTCGATCGAGCGCGTCAGCTGGCGCGGAGCGAGCTTCCTCCCCTGCCGG
TGCATGGGGGGGGTGTGCTGCGCCCAGGTGTTGATCTTGATGACATGTCGGCACTCCGCGCGTTGCTTGATGAGGGCCTG
CCGCTGGAGCAGCTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7U9QI41

Antitoxin

Loading, please wait
Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References