Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2210688..2211306 Replicon chromosome
Accession NZ_CP045524
Organism Shigella sonnei strain 6904.27

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GE168_RS11305 Protein ID WP_001291435.1
Coordinates 2211088..2211306 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag GE168_RS11300 Protein ID WP_000344804.1
Coordinates 2210688..2211062 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE168_RS11290 (2205777) 2205777..2206970 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GE168_RS11295 (2206993) 2206993..2210142 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
GE168_RS11300 (2210688) 2210688..2211062 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
GE168_RS11305 (2211088) 2211088..2211306 + 219 WP_001291435.1 HHA domain-containing protein Toxin
GE168_RS11310 (2211477) 2211477..2212028 + 552 WP_000102564.1 maltose O-acetyltransferase -
GE168_RS11315 (2212144) 2212144..2212614 + 471 WP_000136192.1 YlaC family protein -
GE168_RS11320 (2212778) 2212778..2214326 + 1549 Protein_2215 cyclic-guanylate-specific phosphodiesterase PdeB -
GE168_RS11325 (2214368) 2214368..2214721 - 354 WP_000878140.1 DUF1428 domain-containing protein -
GE168_RS11335 (2215100) 2215100..2215411 + 312 WP_000409911.1 MGMT family protein -
GE168_RS11340 (2215442) 2215442..2216014 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T142065 WP_001291435.1 NZ_CP045524:2211088-2211306 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T142065 NZ_CP060394:6028650-6029039 [Acidobacterium sp. 4Y35]
ATGGTTCTGGACACCTCAGCCATTCTTGCTGTCCTTCTTGAAGAACCTGAGGCTGCTCAACTTGTGCACTTCATCGGTGA
AGACCGCATACGGCTTTGTTCGGCGGTAAGTTTCGTCGAGGCGTCGATTGTTCTTCGCAACCGCAAGGGCGAACGTGGTC
GGCAGAAACTAGACCAGTTTTTGCGACGCGCCCGCGTGCAAATCACAGCTGTTGATGTGAAACAGGCGGAAGTCGCACGA
GAAGCCTATGAGAAATTCGGCAAGGGAAAACATCCCGCGGGGCTGAATCTTGGTGACTGTTTTTCCTATGCGTTAGCGAA
GACAACTAACGAGCCTCTGCTGTTCAAGGGCGAGGATTTTGTGAAAACAGATGTCGTGTCTGTACCTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT142065 WP_000344804.1 NZ_CP045524:2210688-2211062 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT142065 NZ_CP060394:6028384-6028650 [Acidobacterium sp. 4Y35]
GTGCCTCTATACATCAAAAATCCGAATGTCGAGAAGTCTGCGCGGAGGCTTGCGCGCCTGACTGGAGAGACCCTGACCGA
GGCCACGGAGCGGGCCATCGAAGAGAGGCTTGCGCGGCTTCGTCCGGCGCAGAGTCCTGCGCATGGAGCGACGCAGCTTG
AAAAGGATCTGCTGCGCATTGCCCATCAGTGTGCGGCGTTGCCTGACGTGGACACGCGTATGGCCGATGAGATCCTGGGA
TATGACGCCGAAGGGCTGCCCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References