Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3685668..3686322 Replicon chromosome
Accession NZ_CP045522
Organism Shigella flexneri strain 5908.2

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag GE167_RS18660 Protein ID WP_000244767.1
Coordinates 3685668..3686075 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag GE167_RS18665 Protein ID WP_000354044.1
Coordinates 3686056..3686322 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE167_RS18640 (3681625) 3681625..3683358 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
GE167_RS18645 (3683364) 3683364..3684074 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GE167_RS18650 (3684099) 3684099..3684995 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
GE167_RS18655 (3685107) 3685107..3685628 + 522 WP_001055867.1 flavodoxin FldB -
GE167_RS18660 (3685668) 3685668..3686075 - 408 WP_000244767.1 protein YgfX Toxin
GE167_RS18665 (3686056) 3686056..3686322 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
GE167_RS18670 (3686565) 3686565..3687545 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
GE167_RS18675 (3687741) 3687741..3688400 - 660 WP_000250274.1 hemolysin III family protein -
GE167_RS18680 (3688564) 3688564..3688875 - 312 WP_001182950.1 N(4)-acetylcytidine aminohydrolase -
GE167_RS18685 (3688920) 3688920..3690353 + 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
GE167_RS18690 (3690410) 3690410..3691153 - 744 WP_119182047.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T142047 WP_000244767.1 NZ_CP045522:c3686075-3685668 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T142047 NZ_CP060386:774859-775797 [Vibrio alginolyticus]
ATGGATAAAGACAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCCACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGGTTAATGTCAGGGCTGCATTGCAGCGCATTACGGACAGAATCAATACTCAA
CCAGATATCCGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACAATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAGATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTCCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTAGTGGGCTTTTTAACCTA
TACACTAAGTCATCCTCGGCCTATTAATGAAGTTATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTAAAGCAAGTGCTTGATGATTGGCTTGCTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT142047 WP_000354044.1 NZ_CP045522:c3686322-3686056 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142047 NZ_CP060386:774075-774866 [Vibrio alginolyticus]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
TGTCAGCTACTCCCTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTATGTTCTGGCGTGTATTATCGTCCAG
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAG
TGAATCCTGAGAAAGATTTGAAGAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGCGATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGGCGATACTACG
ATCACCAGTGGGTCAATCGCGTAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References