Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2236131..2236657 | Replicon | chromosome |
| Accession | NZ_CP045522 | ||
| Organism | Shigella flexneri strain 5908.2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | GE167_RS11205 | Protein ID | WP_000323025.1 |
| Coordinates | 2236370..2236657 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | GE167_RS11200 | Protein ID | WP_000534858.1 |
| Coordinates | 2236131..2236370 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE167_RS11160 (2232312) | 2232312..2232521 | + | 210 | Protein_2206 | IS1 family transposase | - |
| GE167_RS11165 (2232596) | 2232596..2232961 | - | 366 | Protein_2207 | type 1 fimbrial protein | - |
| GE167_RS23840 (2232974) | 2232974..2233332 | - | 359 | Protein_2208 | type 1 fimbrial protein | - |
| GE167_RS11180 (2233443) | 2233443..2234611 | + | 1169 | WP_000747032.1 | IS3-like element IS911 family transposase | - |
| GE167_RS11190 (2234648) | 2234648..2235804 | + | 1157 | WP_173020732.1 | IS3-like element IS600 family transposase | - |
| GE167_RS11195 (2235801) | 2235801..2236106 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| GE167_RS11200 (2236131) | 2236131..2236370 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| GE167_RS11205 (2236370) | 2236370..2236657 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| GE167_RS11210 (2236729) | 2236729..2236884 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| GE167_RS11215 (2237102) | 2237102..2237352 | + | 251 | Protein_2215 | hypothetical protein | - |
| GE167_RS11220 (2237419) | 2237419..2237697 | + | 279 | WP_024258459.1 | hypothetical protein | - |
| GE167_RS11225 (2237699) | 2237699..2238748 | + | 1050 | WP_025759563.1 | DUF968 domain-containing protein | - |
| GE167_RS11230 (2238761) | 2238761..2239117 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| GE167_RS11235 (2239132) | 2239132..2239953 | + | 822 | WP_000762884.1 | antitermination protein | - |
| GE167_RS11250 (2240895) | 2240895..2240981 | + | 87 | WP_000115835.1 | DUF3927 family protein | - |
| GE167_RS11255 (2241262) | 2241262..2241597 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2230689..2258300 | 27611 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T142033 WP_000323025.1 NZ_CP045522:2236370-2236657 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T142033 NZ_CP060289:3693418-3693708 [Pseudomonas protegens]
ATGCACACCCCAGTCACCCGCTTCGACGCAGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACGCCGGCGACGGCAAGCTGATCCGCGCCGCGCTCAACGACATCGCTCGCGCCCGCGGCATGACCCAGG
TCGCCCGCGACACCGGCCTGGGCCGTGAGAGCCTTTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTCATGAAGGCGCTCGGGCTCAAGCTCAACGTCAGCCCGGCCTGA
ATGCACACCCCAGTCACCCGCTTCGACGCAGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACGCCGGCGACGGCAAGCTGATCCGCGCCGCGCTCAACGACATCGCTCGCGCCCGCGGCATGACCCAGG
TCGCCCGCGACACCGGCCTGGGCCGTGAGAGCCTTTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTCATGAAGGCGCTCGGGCTCAAGCTCAACGTCAGCCCGGCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT142033 WP_000534858.1 NZ_CP045522:2236131-2236370 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT142033 NZ_CP060289:3693112-3693414 [Pseudomonas protegens]
ATGTTCATCTTTGAGCAGACTCAGGCGTTCACCCACTGGCTGCTACGCCTTAAAGATCCCCAGGGAAAAACCCGCGTGCT
GGCGCGGATCAGGGCCGCGCAACTGGGCCGGTTCGGCGACTGCGAACCCGTGGGCGATGGGGTCTATGAAATGCGCATCC
ACCGTGGCCCCGGCTACCGGGTGTACTTTTCGCGCCGGGGCAATCGGATCTACCTGTTGCTGATCGGCGGCGACAAAAGC
ACCCAGAAACGCGATATCCAACAGGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA
ATGTTCATCTTTGAGCAGACTCAGGCGTTCACCCACTGGCTGCTACGCCTTAAAGATCCCCAGGGAAAAACCCGCGTGCT
GGCGCGGATCAGGGCCGCGCAACTGGGCCGGTTCGGCGACTGCGAACCCGTGGGCGATGGGGTCTATGAAATGCGCATCC
ACCGTGGCCCCGGCTACCGGGTGTACTTTTCGCGCCGGGGCAATCGGATCTACCTGTTGCTGATCGGCGGCGACAAAAGC
ACCCAGAAACGCGATATCCAACAGGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|