Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1135908..1136526 Replicon chromosome
Accession NZ_CP045522
Organism Shigella flexneri strain 5908.2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GE167_RS05510 Protein ID WP_001291435.1
Coordinates 1135908..1136126 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag GE167_RS05515 Protein ID WP_000344797.1
Coordinates 1136152..1136526 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE167_RS05485 (1131154) 1131154..1131507 + 354 WP_000878140.1 DUF1428 domain-containing protein -
GE167_RS05490 (1131549) 1131549..1133003 - 1455 Protein_1091 cyclic-guanylate-specific phosphodiesterase PdeB -
GE167_RS05495 (1133096) 1133096..1134324 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
GE167_RS05500 (1134599) 1134599..1135069 - 471 WP_000136192.1 YlaC family protein -
GE167_RS05505 (1135185) 1135185..1135736 - 552 WP_000102569.1 maltose O-acetyltransferase -
GE167_RS05510 (1135908) 1135908..1136126 - 219 WP_001291435.1 HHA domain-containing protein Toxin
GE167_RS05515 (1136152) 1136152..1136526 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
GE167_RS05520 (1137072) 1137072..1140221 - 3150 WP_001132472.1 efflux RND transporter permease AcrB -
GE167_RS05525 (1140244) 1140244..1141437 - 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T142026 WP_001291435.1 NZ_CP045522:c1136126-1135908 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T142026 NZ_CP060288:1135197-1135478 [Pseudomonas mendocina]
GTGAAGCTGGCCTGGACGCGTCTTGCGCTGAACGACCGCCAAGCCATCCGCAGTTATATCGCTCAGGACAATCCCATTGC
CGCCCTGGCGCTGGATGAGTTGTTCACGGAGAAGGCCAGCCGCCTGGCCGATCATCCCAGCTTGGGGCGGCCGGGCCGGG
TAAGTGGCACTCGCGAGCTGGTCGTGCATCAGCACTATCTGATGATCTACGACCTGGCCGATGACCAGGTACGGATACTC
CGGGTGTTGCATACGGCTCGCCAGTGGCCAAGTGCTGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT142026 WP_000344797.1 NZ_CP045522:c1136526-1136152 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT142026 NZ_CP060288:1134910-1135200 [Pseudomonas mendocina]
ATGAGTGAAGCCACCTTTACCTTTCGCGTAGACGACGCCCTGAAAAGCGAATTTGCCCAGGCCGCCAAAGCTCGCGACCG
CACTGGCGCGCAATTGCTGCGCGACTTCATGCGCGACTTCGTCCGGCAGCAGCAAGAGGCTGCCGAGCACGATGCCTGGC
TGCGCCGCCAGGTACAGATGGGGCTGGATTCGGCCAATGCCGGTGAGTTGCTCAGCAGCGAAGAGGTCGAAGCCGAAGCC
GCCGCATGGCGTGCTGAAATGCGCCGCAAACTGGACAGCGCCGCGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References