Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 160008..160639 Replicon chromosome
Accession NZ_CP045522
Organism Shigella flexneri strain 5908.2

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag GE167_RS00725 Protein ID WP_001259385.1
Coordinates 160008..160283 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag GE167_RS00730 Protein ID WP_000593555.1
Coordinates 160280..160639 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE167_RS00710 (155026) 155026..156093 + 1068 WP_000361474.1 HlyD family secretion protein -
GE167_RS00715 (156090) 156090..158825 + 2736 WP_025758458.1 ribosome-associated ATPase/putative transporter RbbA -
GE167_RS00720 (158825) 158825..159949 + 1125 WP_001216257.1 ABC transporter permease -
GE167_RS00725 (160008) 160008..160283 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
GE167_RS00730 (160280) 160280..160639 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GE167_RS00735 (160759) 160759..161160 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
GE167_RS00740 (161166) 161166..161972 - 807 WP_000173672.1 nickel import ATP-binding protein NikE -
GE167_RS00745 (161969) 161969..162733 - 765 WP_001136248.1 nickel import ATP-binding protein NikD -
GE167_RS00750 (162733) 162733..163566 - 834 WP_001008949.1 nickel ABC transporter permease subunit NikC -
GE167_RS00755 (163563) 163563..164507 - 945 WP_025758457.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T142023 WP_001259385.1 NZ_CP045522:160008-160283 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T142023 NZ_CP060285:1181551-1181733 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT142023 WP_000593555.1 NZ_CP045522:160280-160639 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT142023 NZ_CP060285:1181798-1182202 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References