Detailed information of TA system TA142022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 8897..9489
• Replicon: plasmid pSal-5091_MCR64k
• Accession: NZ_CP045521
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain Sal-5091

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1I9ZJC5
• Locus tag: GE195_RS23515
• Protein ID: WP_000513532.1
• Coordinates: 8897..9145 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1I9ZJ49
• Locus tag: GE195_RS23520
• Protein ID: WP_000681609.1
• Coordinates: 9142..9489 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GE195_RS23480	3911..4576	-	666	WP_000532149.1	P-loop NTPase	-
GE195_RS23485	5165..5494	+	330	WP_001542022.1	hypothetical protein	-
GE195_RS23490	5895..6410	+	516	WP_001025393.1	J domain-containing protein	-
GE195_RS23495	6514..7054	+	541	Protein_7	hypothetical protein	-
GE195_RS23500	7051..7305	+	255	WP_001230709.1	hypothetical protein	-
GE195_RS23505	7302..7544	+	243	WP_000151456.1	hypothetical protein	-
GE195_RS23510	8115..8408	+	294	WP_000673428.1	hypothetical protein	-
GE195_RS23515	8897..9145	+	249	WP_000513532.1	type II toxin-antitoxin system HicA family toxin	Toxin
GE195_RS23520	9142..9489	+	348	WP_000681609.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GE195_RS23525	9577..9759	-	183	WP_001428470.1	hypothetical protein	-
GE195_RS23530	10261..10560	+	300	WP_034169410.1	type II toxin-antitoxin system HicB family antitoxin	-
GE195_RS23535	10820..11146	-	327	WP_000206697.1	hypothetical protein	-
GE195_RS23540	11148..11507	-	360	WP_024147837.1	hypothetical protein	-
GE195_RS23545	11608..12315	-	708	WP_000108794.1	hypothetical protein	-
GE195_RS23550	12317..13069	-	753	WP_000797966.1	conjugal transfer protein TraL	-
GE195_RS23555	13087..13488	-	402	WP_021575837.1	hypothetical protein	-
GE195_RS23560	13856..14197	+	342	WP_000730722.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..63762	63762

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 10656.47 Da
• Isoelectric Point: 12.7138

>T142022 WP_000513532.1 NZ_CP045521:8897-9145 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Nucleotide

• Length: 249 bp

>T142022 NZ_CP060285:438208-438597 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 14886.21 Da
• Isoelectric Point: 12.8607

>AT142022 WP_000681609.1 NZ_CP045521:9142-9489 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 348 bp

>AT142022 NZ_CP060285:437956-438201 [Acinetobacter baumannii]
ATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTTTGACCCTTATGT
GAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAGACCCTGATTTAC
TAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAACACTATGTTCAT
GGTTAA

Structures

Toxin

• AlphaFold DB: A0A1I9ZJC5

Antitoxin

• AlphaFold DB: A0A1I9ZJ49