Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 22616..23142 Replicon plasmid p77k
Accession NZ_CP045514
Organism Salmonella enterica subsp. enterica serovar Anatum strain Sal-3948

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag GE197_RS23110 Protein ID WP_000323025.1
Coordinates 22855..23142 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag GE197_RS23105 Protein ID WP_000534857.1
Coordinates 22616..22855 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE197_RS23080 18690..19394 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
GE197_RS23085 19584..20399 - 816 WP_000018329.1 aminoglycoside O-phosphotransferase APH(3')-Ia -
GE197_RS23090 20465..21169 + 705 WP_128111736.1 IS6-like element IS26 family transposase -
GE197_RS23095 21221..22078 - 858 Protein_23 HsdR -
GE197_RS23100 22122..22271 - 150 WP_000550473.1 hypothetical protein -
GE197_RS23105 22616..22855 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
GE197_RS23110 22855..23142 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
GE197_RS23115 23446..24228 - 783 WP_001531258.1 IS21-like element ISSen3 family helper ATPase IstB -
GE197_RS23120 24225..25247 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
GE197_RS23125 25386..25610 + 225 Protein_29 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..77622 77622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 12322.73 Da        Isoelectric Point: 12.7777

>T142017 WP_000323025.1 NZ_CP045514:22855-23142 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Download         Length: 288 bp

>T142017 NZ_CP060281:c5337710-5337327 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCAGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 10271.94 Da        Isoelectric Point: 12.6975

>AT142017 WP_000534857.1 NZ_CP045514:22616-22855 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 240 bp

>AT142017 NZ_CP060281:c5337952-5337710 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References