Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3660401..3661023 Replicon chromosome
Accession NZ_CP045508
Organism Desulfolutivibrio sulfoxidireducens strain DSM 107105

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GD604_RS16010 Protein ID WP_176638093.1
Coordinates 3660401..3660655 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GD604_RS16015 Protein ID WP_176632391.1
Coordinates 3660652..3661023 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD604_RS15995 3655534..3657522 + 1989 WP_176638091.1 MBL fold metallo-hydrolase -
GD604_RS16000 3657670..3658815 - 1146 WP_176638092.1 pyridoxal phosphate-dependent aminotransferase -
GD604_RS16005 3658812..3660275 - 1464 WP_176632389.1 dynamin family protein -
GD604_RS16010 3660401..3660655 + 255 WP_176638093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GD604_RS16015 3660652..3661023 + 372 WP_176632391.1 helix-turn-helix transcriptional regulator Antitoxin
GD604_RS16020 3661209..3663773 + 2565 WP_176632392.1 PAS domain S-box protein -
GD604_RS16025 3663958..3664536 + 579 WP_176632393.1 type I restriction endonuclease subunit R -
GD604_RS16030 3664740..3664901 + 162 WP_176632394.1 FeoB-associated Cys-rich membrane protein -
GD604_RS16035 3665074..3665511 - 438 WP_176632395.1 thioredoxin fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(68-122)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9472.18 Da        Isoelectric Point: 10.6867

>T142013 WP_176638093.1 NZ_CP045508:3660401-3660655 [Desulfolutivibrio sulfoxidireducens]
MYALRFSMAAIKALKKAPDDVAGRIRSRLDELAKDPFAAPGVKKLTGHPGYRLRVGDWRVLYLIEKGELVIHVVELGQRK
EVSR

Download         Length: 255 bp

>T142013 NZ_CP060281:c2832773-2831451 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGATAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGAGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCATGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13276.35 Da        Isoelectric Point: 6.0894

>AT142013 WP_176632391.1 NZ_CP045508:3660652-3661023 [Desulfolutivibrio sulfoxidireducens]
MSVHILERDGRPAFAVLPIEEYERLVAALEDARDAAVIEAFHKSLISGEVETIPAEVVNRLLGGENPVKVLRAHRGLTLQ
QVAEACGVTNSHISQIERGKRSMSAGLLKRMAAALGVDAELLL

Download         Length: 372 bp

>AT142013 NZ_CP060281:c2833039-2832773 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References