Detailed information of TA system TA142011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2342509..2343145
• Replicon: chromosome
• Accession: NZ_CP045508
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 107105

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GD604_RS10340
• Protein ID: WP_176630871.1
• Coordinates: 2342509..2342700 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GD604_RS10345
• Protein ID: WP_176630870.1
• Coordinates: 2342753..2343145 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD604_RS10335	2340773..2342443	+	1671	WP_176630872.1	Na/Pi symporter	-
GD604_RS10340	2342509..2342700	+	192	WP_176630871.1	type II toxin-antitoxin system HicA family toxin	Toxin
GD604_RS10345	2342753..2343145	+	393	WP_176630870.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GD604_RS10350	2343399..2346227	+	2829	WP_176630869.1	isoleucine--tRNA ligase	-
GD604_RS10355	2346268..2346762	+	495	WP_176630868.1	signal peptidase II	-
GD604_RS10360	2346955..2347185	+	231	WP_176630867.1	PLD nuclease N-terminal domain-containing protein	-
GD604_RS10365	2347182..2348144	+	963	WP_176630866.1	tol-pal system protein YbgF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-121)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7230.43 Da
• Isoelectric Point: 10.8134

>T142011 WP_176630871.1 NZ_CP045508:2342509-2342700 [Desulfolutivibrio sulfoxidireducens]
VTSSREIIRKLAAAGWRLKRVTGDHHHFDHPDKPGLVTVKHPTKDLDTTLLKYMEKQAGMKLR

Nucleotide

• Length: 192 bp

>T142011 NZ_CP060281:800371-800781 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13745.83 Da
• Isoelectric Point: 5.6261

>AT142011 WP_176630870.1 NZ_CP045508:2342753-2343145 [Desulfolutivibrio sulfoxidireducens]
MAIYPAFFESGEDGHVVVSFPDLPGCLTQGETESEAMAMAIDALGGHIATLRDLGRDVPQPTPLSRLTVPQGLRVALVPG
PIDGEPPVRINISINKGLLREVDACAKREGMTRSGFLASAAKSKIVHLQS

Nucleotide

• Length: 393 bp

>AT142011 NZ_CP060281:800124-800390 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA