Detailed information of TA system TA142009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 607551..608028
• Replicon: chromosome
• Accession: NZ_CP045508
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 107105

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: GD604_RS02535
• Protein ID: WP_176636952.1
• Coordinates: 607551..607820 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: GD604_RS02540
• Protein ID: WP_176629974.1
• Coordinates: 607804..608028 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD604_RS02510	603381..603938	-	558	WP_176629968.1	NapC/NirT family cytochrome c	-
GD604_RS02515	603978..604877	-	900	WP_176636949.1	transposase	-
GD604_RS02520	605055..606257	-	1203	WP_176636950.1	acyltransferase family protein	-
GD604_RS02525	606254..606916	-	663	WP_176636951.1	CerR family C-terminal domain-containing protein	-
GD604_RS02530	607273..607539	+	267	WP_176629972.1	hypothetical protein	-
GD604_RS02535	607551..607820	-	270	WP_176636952.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GD604_RS02540	607804..608028	-	225	WP_176629974.1	ribbon-helix-helix domain-containing protein	Antitoxin
GD604_RS02545	608391..609155	-	765	WP_176636953.1	3-hydroxyacyl-ACP dehydratase	-
GD604_RS02550	609310..609483	-	174	WP_176629976.1	hypothetical protein	-
GD604_RS02555	609523..609840	-	318	WP_176629977.1	TraR/DksA C4-type zinc finger protein	-
GD604_RS02560	610314..610574	+	261	WP_176629978.1	hypothetical protein	-
GD604_RS02565	610574..610906	+	333	WP_176629979.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (2-69)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10635.45 Da
• Isoelectric Point: 10.3841

>T142009 WP_176636952.1 NZ_CP045508:c607820-607551 [Desulfolutivibrio sulfoxidireducens]
MNWKIEFTAEADKTLTRLGREAERRILKFMRERISKLEDPRIIGEPLKGSRFSGLWRYRAGDYRILCEIQDEKIRILVVL
VGHRGEIYK

Nucleotide

• Length: 270 bp

>T142009 NZ_CP060281:332813-333181 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCATGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTATGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8632.83 Da
• Isoelectric Point: 4.3752

>AT142009 WP_176629974.1 NZ_CP045508:c608028-607804 [Desulfolutivibrio sulfoxidireducens]
MLTIRLPAELETRLNILADTTKRPKSFYVREALERSLEDIEDVYLAEAALERFRASGEKGIPLEELERRLELED

Nucleotide

• Length: 225 bp

>AT142009 NZ_CP060281:332595-332816 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA