Detailed information of TA system TA142008

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 115435..116105
• Replicon: chromosome
• Accession: NZ_CP045508
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 107105

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GD604_RS00530
• Protein ID: WP_176632825.1
• Coordinates: 115435..115623 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GD604_RS00535
• Protein ID: WP_176629597.1
• Coordinates: 115677..116105 (+)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD604_RS00515	111754..112008	+	255	WP_176629594.1	BrnT family toxin	-
GD604_RS00520	112005..112289	+	285	WP_176629595.1	BrnA antitoxin family protein	-
GD604_RS00525	112302..115304	-	3003	WP_176636800.1	DEAD/DEAH box helicase	-
GD604_RS00530	115435..115623	+	189	WP_176632825.1	type II toxin-antitoxin system HicA family toxin	Toxin
GD604_RS00535	115677..116105	+	429	WP_176629597.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GD604_RS00540	116450..117823	-	1374	WP_176629598.1	sigma-54 dependent transcriptional regulator	-
GD604_RS00545	117837..119282	-	1446	WP_176629599.1	two-component sensor histidine kinase	-
GD604_RS00550	119340..120512	-	1173	WP_176636801.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-56)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-125)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.39 Da
• Isoelectric Point: 10.9513

>T142008 WP_176632825.1 NZ_CP045508:115435-115623 [Desulfolutivibrio sulfoxidireducens]
MDSRAIIKKLEQRGWRHVRTVGSHHIFEHPDYPEIVTVPHPKKDLPPGTLRGILKTGRIERQ

Nucleotide

• Length: 189 bp

>T142008 NZ_CP060281:201585-202070 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAACCAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15070.22 Da
• Isoelectric Point: 4.9205

>AT142008 WP_176629597.1 NZ_CP045508:115677-116105 [Desulfolutivibrio sulfoxidireducens]
MTAYIAMIHKDPDSDYGVSFPDFPGCVTAGSTLEEAREMADEALGAHVGYLRETGRAVPEPTTLDAIMADPETAGAVSFL
VVSVPEAKQKPVRINVMIPDADLRRIDATARRLGMSRSSLLVRAARKFLLAGSGPATPADTP

Nucleotide

• Length: 429 bp

>AT142008 NZ_CP060281:201331-201597 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA