Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3558750..3559531 Replicon chromosome
Accession NZ_CP045506
Organism Desulfolutivibrio sulfoxidireducens strain DSM 106783

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag GD605_RS15360 Protein ID WP_176632224.1
Coordinates 3558750..3559250 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag GD605_RS15365 Protein ID WP_176632225.1
Coordinates 3559247..3559531 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD605_RS15325 3553774..3554283 + 510 WP_176632217.1 OmpH family outer membrane protein -
GD605_RS15330 3554373..3554840 + 468 WP_176632218.1 3-hydroxyacyl-ACP dehydratase FabZ -
GD605_RS15335 3554892..3556676 - 1785 WP_176632219.1 GAF domain-containing protein -
GD605_RS15340 3556702..3557088 - 387 WP_176632220.1 response regulator -
GD605_RS15345 3557266..3557469 - 204 WP_176632221.1 hypothetical protein -
GD605_RS15350 3557652..3557993 - 342 WP_176632222.1 IscA/HesB family protein -
GD605_RS15355 3558189..3558722 + 534 WP_176632223.1 bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR -
GD605_RS15360 3558750..3559250 - 501 WP_176632224.1 GNAT family N-acetyltransferase Toxin
GD605_RS15365 3559247..3559531 - 285 WP_176632225.1 DUF1778 domain-containing protein Antitoxin
GD605_RS15370 3559615..3560526 - 912 WP_176632226.1 acetylglutamate kinase -
GD605_RS15375 3560642..3562030 - 1389 WP_176632227.1 ATP-dependent protease ATPase subunit HslU -
GD605_RS15380 3562140..3562682 - 543 WP_176632228.1 ATP-dependent protease subunit HslV -
GD605_RS15385 3562986..3563540 - 555 WP_176632229.1 O-acetyl-ADP-ribose deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3501463..3589854 88391


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(5-92)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18137.88 Da        Isoelectric Point: 10.5520

>T142004 WP_176632224.1 NZ_CP045506:c3559250-3558750 [Desulfolutivibrio sulfoxidireducens]
VIRTPSPLAAEHDVVSFQSGEPVLDDWLRRRALANQASGASRTYVIADEKRVIGYYALAAGAVTATDAPGKVRRNMPDPI
PVMVLGRLAVDRDWQGRGLGFDLLRDAVLRTLRAAEIAGIRALLVHALHERAGAFYEHAGFRRSPVRPLTYVLTLAEAQK
ALAFRG

Download         Length: 501 bp

>T142004 NZ_CP060278:c2504430-2504068 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10679.20 Da        Isoelectric Point: 10.0050

>AT142004 WP_176632225.1 NZ_CP045506:c3559531-3559247 [Desulfolutivibrio sulfoxidireducens]
MPQANSPSRSGNINIRVALEQRNLIDQAASLCNKTRTDFILEAATKAARDAILDQVLYPVSAERFEAFQRLLDSPPEENE
RLRVLMARKPRWGK

Download         Length: 285 bp

>AT142004 NZ_CP060278:c2504597-2504427 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References