Detailed information of TA system TA142003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1790652..1791288
• Replicon: chromosome
• Accession: NZ_CP045506
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 106783

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GD605_RS07620
• Protein ID: WP_176630871.1
• Coordinates: 1791097..1791288 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GD605_RS07615
• Protein ID: WP_176630870.1
• Coordinates: 1790652..1791044 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD605_RS07595	1785653..1786615	-	963	WP_176630866.1	tol-pal system protein YbgF	-
GD605_RS07600	1786612..1786842	-	231	WP_176630867.1	PLD nuclease N-terminal domain-containing protein	-
GD605_RS07605	1787035..1787529	-	495	WP_176630868.1	signal peptidase II	-
GD605_RS07610	1787570..1790398	-	2829	WP_176630869.1	isoleucine--tRNA ligase	-
GD605_RS07615	1790652..1791044	-	393	WP_176630870.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GD605_RS07620	1791097..1791288	-	192	WP_176630871.1	type II toxin-antitoxin system HicA family toxin	Toxin
GD605_RS07625	1791354..1793024	-	1671	WP_176630872.1	Na/Pi symporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-121)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7230.43 Da
• Isoelectric Point: 10.8134

>T142003 WP_176630871.1 NZ_CP045506:c1791288-1791097 [Desulfolutivibrio sulfoxidireducens]
VTSSREIIRKLAAAGWRLKRVTGDHHHFDHPDKPGLVTVKHPTKDLDTTLLKYMEKQAGMKLR

Nucleotide

• Length: 192 bp

>T142003 NZ_CP060278:c2433460-2433209 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13745.83 Da
• Isoelectric Point: 5.6261

>AT142003 WP_176630870.1 NZ_CP045506:c1791044-1790652 [Desulfolutivibrio sulfoxidireducens]
MAIYPAFFESGEDGHVVVSFPDLPGCLTQGETESEAMAMAIDALGGHIATLRDLGRDVPQPTPLSRLTVPQGLRVALVPG
PIDGEPPVRINISINKGLLREVDACAKREGMTRSGFLASAAKSKIVHLQS

Nucleotide

• Length: 393 bp

>AT142003 NZ_CP060278:c2433219-2433037 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA