Detailed information of TA system TA142002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1395272..1395939
• Replicon: chromosome
• Accession: NZ_CP045506
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 106783

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GD605_RS05915
• Protein ID: WP_176630572.1
• Coordinates: 1395535..1395939 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GD605_RS05910
• Protein ID: WP_176630571.1
• Coordinates: 1395272..1395535 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD605_RS05885	1390294..1390752	+	459	WP_176632877.1	hydrogenase iron-sulfur subunit	-
GD605_RS05890	1390752..1391735	+	984	WP_176630568.1	4Fe-4S dicluster domain-containing protein	-
GD605_RS05895	1391732..1392790	+	1059	WP_176630569.1	4Fe-4S dicluster domain-containing protein	-
GD605_RS05900	1392787..1393626	+	840	WP_176630570.1	FAD/NAD(P)-binding protein	-
GD605_RS05905	1393858..1395072	-	1215	WP_176632828.1	ISL3 family transposase	-
GD605_RS05910	1395272..1395535	+	264	WP_176630571.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GD605_RS05915	1395535..1395939	+	405	WP_176630572.1	type II toxin-antitoxin system VapC family toxin	Toxin
GD605_RS05920	1396522..1396986	+	465	WP_176630573.1	winged helix DNA-binding protein	-
GD605_RS05925	1397049..1399514	+	2466	WP_176630574.1	MMPL family transporter	-
GD605_RS05930	1399587..1400420	+	834	WP_176630575.1	outer membrane lipoprotein-sorting protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-50)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15065.33 Da
• Isoelectric Point: 7.1692

>T142002 WP_176630572.1 NZ_CP045506:1395535-1395939 [Desulfolutivibrio sulfoxidireducens]
MFLLDTVVLSELRKKDRNPGLVRWISGADDGKLFVSVVTVGEIERGIRRQQGRDAALAQRLTDWLAQLVLAYGDRILPIT
TEVARRWGQCSADLGRADADILIAATALEHDMVVVTRNERHFIPTGVRVFNPWE

Nucleotide

• Length: 405 bp

>T142002 NZ_CP060278:c2410026-2409850 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9328.65 Da
• Isoelectric Point: 7.9830

>AT142002 WP_176630571.1 NZ_CP045506:1395272-1395535 [Desulfolutivibrio sulfoxidireducens]
MPSTWTLQDAKNKFSEVVNAACAGAPQVVTKRGKPSVVVLSMTDYARFVAQGKSPAPRFTEFLLSIPGGGAEADATRENI
ALREVEF

Nucleotide

• Length: 264 bp

>AT142002 NZ_CP060278:2409727-2409782 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG