Detailed information of TA system TA141999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 115201..115871
• Replicon: chromosome
• Accession: NZ_CP045506
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 106783

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GD605_RS00530
• Protein ID: WP_176632825.1
• Coordinates: 115201..115389 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GD605_RS00535
• Protein ID: WP_176629597.1
• Coordinates: 115443..115871 (+)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD605_RS00515	111520..111774	+	255	WP_176629594.1	BrnT family toxin	-
GD605_RS00520	111771..112055	+	285	WP_176629595.1	BrnA antitoxin family protein	-
GD605_RS00525	112068..115070	-	3003	WP_176629596.1	DEAD/DEAH box helicase	-
GD605_RS00530	115201..115389	+	189	WP_176632825.1	type II toxin-antitoxin system HicA family toxin	Toxin
GD605_RS00535	115443..115871	+	429	WP_176629597.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GD605_RS00540	116216..117589	-	1374	WP_176629598.1	sigma-54 dependent transcriptional regulator	-
GD605_RS00545	117603..119048	-	1446	WP_176629599.1	two-component sensor histidine kinase	-
GD605_RS00550	119106..120278	-	1173	WP_176629600.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-56)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-125)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.39 Da
• Isoelectric Point: 10.9513

>T141999 WP_176632825.1 NZ_CP045506:115201-115389 [Desulfolutivibrio sulfoxidireducens]
MDSRAIIKKLEQRGWRHVRTVGSHHIFEHPDYPEIVTVPHPKKDLPPGTLRGILKTGRIERQ

Nucleotide

• Length: 189 bp

>T141999 NZ_CP060278:c1227035-1226847 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15070.22 Da
• Isoelectric Point: 4.9205

>AT141999 WP_176629597.1 NZ_CP045506:115443-115871 [Desulfolutivibrio sulfoxidireducens]
MTAYIAMIHKDPDSDYGVSFPDFPGCVTAGSTLEEAREMADEALGAHVGYLRETGRAVPEPTTLDAIMADPETAGAVSFL
VVSVPEAKQKPVRINVMIPDADLRRIDATARRLGMSRSSLLVRAARKFLLAGSGPATPADTP

Nucleotide

• Length: 429 bp

>AT141999 NZ_CP060278:c1227324-1227064 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA