Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3783374..3784010 Replicon chromosome
Accession NZ_CP045504
Organism Desulfovibrio sulfodismutans DSM 3696

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GD606_RS17320 Protein ID WP_163302245.1
Coordinates 3783822..3784010 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GD606_RS17315 Protein ID WP_163302246.1
Coordinates 3783374..3783772 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD606_RS17290 3778595..3779443 + 849 WP_163302250.1 hypothetical protein -
GD606_RS17295 3779681..3781063 - 1383 WP_163302249.1 MBL fold metallo-hydrolase -
GD606_RS17300 3781390..3782019 - 630 WP_163302248.1 peroxiredoxin -
GD606_RS17305 3782412..3782669 + 258 WP_176629335.1 redoxin domain-containing protein -
GD606_RS17310 3782739..3783134 + 396 WP_176629336.1 redoxin domain-containing protein -
GD606_RS17315 3783374..3783772 - 399 WP_163302246.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GD606_RS17320 3783822..3784010 - 189 WP_163302245.1 type II toxin-antitoxin system HicA family toxin Toxin
GD606_RS17325 3784176..3787391 - 3216 WP_163302244.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7141.33 Da        Isoelectric Point: 11.3897

>T141997 WP_163302245.1 NZ_CP045504:c3784010-3783822 [Desulfovibrio sulfodismutans DSM 3696]
MDSDEVIRRLLAAGWRKARVKGSHWHFRHPDIPGLVTVPHPKKDLKPKTVHSIERQSGLNLK

Download         Length: 189 bp

>T141997 NZ_CP060278:c104559-104452 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14192.13 Da        Isoelectric Point: 4.8261

>AT141997 WP_163302246.1 NZ_CP045504:c3783772-3783374 [Desulfovibrio sulfodismutans DSM 3696]
MYYHAIFDPDDRGGFTVTFPDLPGCITEGDDEQQALTMAADALDGHIQTLKDLGMPVPPPSPHTAILEKSPAGAMVFPVP
LAAFESRQKRVNITMGEGLLARVDRAARSESMTRSGFLAVAARSYLNQLTSA

Download         Length: 399 bp

>AT141997 NZ_CP060278:104375-104435 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References