Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3598893..3599487 Replicon chromosome
Accession NZ_CP045504
Organism Desulfovibrio sulfodismutans DSM 3696

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GD606_RS16490 Protein ID WP_163300736.1
Coordinates 3598893..3599216 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GD606_RS16495 Protein ID WP_163300737.1
Coordinates 3599197..3599487 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD606_RS16475 3594654..3595937 - 1284 WP_163300733.1 response regulator -
GD606_RS16480 3596196..3597332 + 1137 WP_163300734.1 aminotransferase class V-fold PLP-dependent enzyme -
GD606_RS16485 3597527..3598711 + 1185 WP_163300735.1 hydroxyacid dehydrogenase -
GD606_RS16490 3598893..3599216 + 324 WP_163300736.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GD606_RS16495 3599197..3599487 + 291 WP_163300737.1 putative addiction module antidote protein Antitoxin
GD606_RS16500 3599658..3601169 - 1512 WP_163300789.1 DHA2 family efflux MFS transporter permease subunit -
GD606_RS16505 3601219..3602460 - 1242 WP_163300738.1 HlyD family secretion protein -
GD606_RS16510 3602457..3602948 - 492 WP_163300739.1 MarR family transcriptional regulator -
GD606_RS16515 3603042..3603953 - 912 WP_163300740.1 phosphoadenosine phosphosulfate reductase family protein -
GD606_RS16520 3604058..3604255 - 198 WP_163300790.1 MoaD/ThiS family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-95)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12615.42 Da        Isoelectric Point: 9.5954

>T141996 WP_163300736.1 NZ_CP045504:3598893-3599216 [Desulfovibrio sulfodismutans DSM 3696]
MNLFRQTDIFSRWLEKLEDIQAKARILVRIRAAELGNFGDCSPVGEGVSEMRLHFGPGYRVYFWKQESRIYWLLAGGDKS
SQKRDIKRAMSLRREVEEAIRDENQHI

Download         Length: 324 bp

>T141996 NZ_CP060278:c79140-78874 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10464.08 Da        Isoelectric Point: 9.5359

>AT141996 WP_163300737.1 NZ_CP045504:3599197-3599487 [Desulfovibrio sulfodismutans DSM 3696]
MKISTFDAAHYLDSEEMIAEYLSAAMEDPNPDVFLTALSDVARARGITQLARVTGLGRESLYKTLSPGSKPRFDTIMKIT
KALGAPLGVKRKQGHP

Download         Length: 291 bp

>AT141996 NZ_CP060278:c79391-79140 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References