Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1874905..1875503 Replicon chromosome
Accession NZ_CP045504
Organism Desulfovibrio sulfodismutans DSM 3696

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GD606_RS08895 Protein ID WP_163301260.1
Coordinates 1875246..1875503 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GD606_RS08890 Protein ID WP_163301261.1
Coordinates 1874905..1875249 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD606_RS08870 1869951..1870268 + 318 WP_163301264.1 ArsR family transcriptional regulator -
GD606_RS08875 1870442..1872367 - 1926 WP_163301275.1 TIGR03768 family metallophosphoesterase -
GD606_RS08880 1872743..1873585 - 843 WP_163301263.1 alpha/beta hydrolase -
GD606_RS08885 1873927..1874757 - 831 WP_163301262.1 cyclase family protein -
GD606_RS08890 1874905..1875249 - 345 WP_163301261.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GD606_RS08895 1875246..1875503 - 258 WP_163301260.1 type II toxin-antitoxin system HicA family toxin Toxin
GD606_RS08900 1875682..1875987 + 306 WP_163301274.1 ArsR family transcriptional regulator -
GD606_RS08905 1876011..1877117 + 1107 WP_163301259.1 linear amide C-N hydrolase -
GD606_RS08910 1877410..1877946 + 537 WP_163301258.1 hypothetical protein -
GD606_RS08915 1877955..1880327 + 2373 WP_163301257.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1870442..1890804 20362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-74)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9547.20 Da        Isoelectric Point: 10.7201

>T141994 WP_163301260.1 NZ_CP045504:c1875503-1875246 [Desulfovibrio sulfodismutans DSM 3696]
MNSRLRRTLEAILAKPERGDIAWSAVEALLLALGCRKLEGDGSRVRFVSADGAILRIHRPHPRPVLDKGAVKSVRRFLCE
MEIEQ

Download         Length: 258 bp

>T141994 NZ_CP060276:4751844-4752122 [Serratia ureilytica]
GTGAAACTGATATGGACGGAACCCGCCATCGCCGATCGTCTGGCGATTTATGAATGGTTGGAACTTAAAAACCCGGCCGC
TGCCGCGGAAAATGATGTAAAAATCGCTGACGCGGCGGCACGCCTCGTGCATCATCCCGCCAGCGGAAAAACGGGTCGGA
TAGCCGGCACGCGCGAGTTGGTCATCTCTCCGTCCTATCTGCTGGTCTATGAATGGGCGGCTCAACGCGTCATCATCTTG
GCCATCGTGCATACCCGCCGCCGGTGGCCACCCGTATAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12588.15 Da        Isoelectric Point: 5.2157

>AT141994 WP_163301261.1 NZ_CP045504:c1875249-1874905 [Desulfovibrio sulfodismutans DSM 3696]
MNAFQYKGYLGTFEFESGDDAFHGEISGIRDVIHFTGRSVDELRLAFQEAVDDYLATCAEIGKPPEKPYSGRFMVRVSPE
IHRLAESAAKVTGKSLNAFAAETLERAAREAIKA

Download         Length: 345 bp

>AT141994 NZ_CP060276:4751557-4751826 [Serratia ureilytica]
ATGCCTGAATCTACCGTGGTAATCCGCGTGGATGAAGAGTTAAAAACCGCTTTTGCCAGCGCAGCAAAGGCCGCCGACCG
CACGGCTTCACAACTGCTGCGCGATTTCATGCGCGAGTTTGTCAGCCGCCAGGCTCAGCAGGAAGAATACGACCAGTGGC
TGAGGGAAAAAGTCGAGGTGAGCCGCAAGGCGTTGCGTGAAGGCAAGTTAGCCGACGATGAAGAGGTCGCCGCTTATTTC
GCCGAACGCAGAGCTAAATCAACGCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References