Detailed information of TA system TA141990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 361127..362736
• Replicon: chromosome
• Accession: NZ_CP045503
• Organism: Shewanella sp. YLB-08

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FM038_RS01570
• Protein ID: WP_142874865.1
• Coordinates: 361408..362736 (+)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FM038_RS01565
• Protein ID: WP_142874866.1
• Coordinates: 361127..361408 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FM038_RS01545	356379..358076	-	1698	WP_142874867.1	MtrB/PioB family outer membrane beta-barrel protein	-
FM038_RS01550	358086..358946	-	861	WP_142873541.1	DmsE family decaheme c-type cytochrome	-
FM038_RS01555	359438..360076	-	639	WP_142874875.1	multidrug MFS transporter	-
FM038_RS01560	360241..360936	+	696	WP_142874874.1	amino acid adenylation	-
FM038_RS01565	361127..361408	+	282	WP_142874866.1	helix-turn-helix domain-containing protein	Antitoxin
FM038_RS01570	361408..362736	+	1329	WP_142874865.1	type II toxin-antitoxin system HipA family toxin	Toxin
FM038_RS01575	363043..363615	-	573	WP_142874864.1	hypothetical protein	-
FM038_RS01580	364065..364616	-	552	WP_142874863.1	hypothetical protein	-
FM038_RS01585	364629..365297	-	669	WP_185965875.1	nucleotidyltransferase domain-containing protein	-
FM038_RS01590	365380..365997	-	618	WP_142874861.1	tyrosine-type recombinase/integrase	-
FM038_RS01595	366009..366197	-	189	WP_142874860.1	hypothetical protein	-
FM038_RS01600	366252..367619	-	1368	WP_185965874.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49676.02 Da
• Isoelectric Point: 6.5059

>T141990 WP_142874865.1 NZ_CP045503:361408-362736 [Shewanella eurypsychrophilus]
MAILDVYMNGYFIGEFTKSTTGSHLFKYEQQWLDISGSRPISLSMPLRKHEYKGDEVYNFFDNLLPDNTDVRNRIVARHN
AQSTQAFDLLYKVGQDSVGALQLVPHDQNAFDVKKIESKPLSDKELEKVLKGYQSDIPLGMLADEDDFRISIAGAQEKTA
LLNLDGQWHLPIKATPTTHIIKLPIGEIQSHSHTIDMSDSVENEYLCMMIVREFGLDVPQCSIIQVGDIKALTVERFDRK
LSTDGKWIMRLPQEDFCQTLNIPPAKKYESHGGPGIEQIMPYLLGSKNAERDRYNFMKSQVLFWLLAATDGHAKNFSLFI
EAGGGYRLTPFYDILSISPAIGGKGLNIRNAKLAMGLKATKGKEYRIAQIFPRHFIQTAKAIGYDTDAMAYIMSELADVV
DSVVTKVKSQLPIDFPVHIRDSILDGLEARANRLVNLAPVNM

Nucleotide

• Length: 1329 bp

>T141990 NZ_CP060276:4028625-4028969 [Serratia ureilytica]
ATGTGGCAAGTGGTGACCGTCGAACGATTCGACGACTGGTTTTTGGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAAGGAGTTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCTGCCATGGAATTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10577.97 Da
• Isoelectric Point: 5.8701

>AT141990 WP_142874866.1 NZ_CP045503:361127-361408 [Shewanella eurypsychrophilus]
MKVTNSKQLSAYLKDARLNMKLSQSKVGNKVGIRQDTVSSFEQNPDSTKLETLFKILSALNLELDVKVRNPELGGEIHDD
KAITSDQEWKEEW

Nucleotide

• Length: 282 bp

>AT141990 NZ_CP060276:4028975-4029277 [Serratia ureilytica]
ATGGCCAAACCGTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAGGCGGACAAGGA
AATTTTCGAACTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGTCGCATGACGCTGTGA