Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3469535..3470202 Replicon chromosome
Accession NZ_CP045496
Organism Mesorhizobium sp. INR15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GA829_RS16960 Protein ID WP_210337672.1
Coordinates 3469807..3470202 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GA829_RS16955 Protein ID WP_195173863.1
Coordinates 3469535..3469807 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GA829_RS16930 3464872..3465858 + 987 WP_195173860.1 ABC transporter permease -
GA829_RS16935 3465930..3466409 + 480 WP_195179700.1 gluconokinase -
GA829_RS16940 3466404..3467552 - 1149 WP_195173861.1 hypothetical protein -
GA829_RS16945 3467621..3468070 - 450 WP_006202816.1 Rrf2 family transcriptional regulator -
GA829_RS16950 3468325..3469311 - 987 WP_195173862.1 sulfate ABC transporter substrate-binding protein -
GA829_RS16955 3469535..3469807 + 273 WP_195173863.1 antitoxin Antitoxin
GA829_RS16960 3469807..3470202 + 396 WP_210337672.1 type II toxin-antitoxin system VapC family toxin Toxin
GA829_RS16965 3470233..3471273 - 1041 WP_195173865.1 sulfate/molybdate ABC transporter ATP-binding protein -
GA829_RS16970 3471286..3472170 - 885 WP_195173866.1 sulfate ABC transporter permease subunit CysW -
GA829_RS16975 3472163..3473014 - 852 WP_195173867.1 sulfate ABC transporter permease subunit CysT -
GA829_RS16980 3473031..3474062 - 1032 WP_195173868.1 sulfate ABC transporter substrate-binding protein -
GA829_RS16985 3474305..3475027 - 723 WP_195173869.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-116)

Antitoxin

SpoVT-AbrB domain

(17-55)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14000.20 Da        Isoelectric Point: 5.1469

>T141987 WP_210337672.1 NZ_CP045496:3469807-3470202 [Mesorhizobium sp. INR15]
MRFMLDTSIISDMIRNPAGNAASAMAREGDDAVCTSIVVASELRYGCAKKGSAKLLSKVEQLLAEIPVLPLDVPVDAEYG
AIRAELEGAGQAIGHNLFIAAHAYVLGITLVTANWGEFTRIRGLKVENWLA

Download         Length: 396 bp

>T141987 NZ_CP060276:c1712770-1712486 [Serratia ureilytica]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACCGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10133.56 Da        Isoelectric Point: 5.6343

>AT141987 WP_195173863.1 NZ_CP045496:3469535-3469807 [Mesorhizobium sp. INR15]
MPQHRHSTTLPKEAKLFRNNRSQAVRIPVEFELPGDKVLISREGDRLVIEAVRKPGLTALLSQWAKEAPLGPEDDFPEIG
DAPIHPEDIF

Download         Length: 273 bp

>AT141987 NZ_CP060276:c1713011-1712760 [Serratia ureilytica]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCTGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAATACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References