Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2376345..2376973 Replicon chromosome
Accession NZ_CP045496
Organism Mesorhizobium sp. INR15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GA829_RS11530 Protein ID WP_195178618.1
Coordinates 2376587..2376973 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GA829_RS11525 Protein ID WP_195178617.1
Coordinates 2376345..2376590 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GA829_RS11500 2372196..2373311 - 1116 WP_195178612.1 AbrB family transcriptional regulator -
GA829_RS11505 2373382..2373690 - 309 WP_195178613.1 antibiotic biosynthesis monooxygenase -
GA829_RS11510 2373790..2374572 - 783 WP_195178614.1 SDR family oxidoreductase -
GA829_RS11515 2374658..2375095 - 438 WP_195178615.1 DsrE family protein -
GA829_RS11520 2375190..2376278 + 1089 WP_195178616.1 hypothetical protein -
GA829_RS11525 2376345..2376590 + 246 WP_195178617.1 antitoxin Antitoxin
GA829_RS11530 2376587..2376973 + 387 WP_195178618.1 type II toxin-antitoxin system VapC family toxin Toxin
GA829_RS11535 2376977..2377906 - 930 WP_195178619.1 cation diffusion facilitator family transporter -
GA829_RS11540 2377913..2380102 - 2190 WP_195178620.1 anthranilate synthase -
GA829_RS11545 2380430..2381200 + 771 WP_195178621.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14287.32 Da        Isoelectric Point: 6.2316

>T141986 WP_195178618.1 NZ_CP045496:2376587-2376973 [Mesorhizobium sp. INR15]
VIYLLDTNAVIAVMKRDADLLGWLKRGGPQDHALSAIVVHELYYGAYKSQQQDGNLLRIEALQFQVLEFDREDARHAGEI
RALLAASGTPIGPYDALIGGQARARGLTLVTRNVREFERIKDLAIETW

Download         Length: 387 bp

>T141986 NZ_CP060276:1579869-1580171 [Serratia ureilytica]
ATTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGATGTCCT
CTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGGAGATTG
AGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCCGTTGGT
AATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9352.60 Da        Isoelectric Point: 4.4978

>AT141986 WP_195178617.1 NZ_CP045496:2376345-2376590 [Mesorhizobium sp. INR15]
MEKAKVFWSGRSQAVRLPKEFRFETDEVSIRRHGKTVILEPLAQDWAWLDQLAGPVDDDFVEAVLEQPAEQVRPALDDVF
K

Download         Length: 246 bp

>AT141986 NZ_CP060276:1579623-1579859 [Serratia ureilytica]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACAGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References