Detailed information of TA system TA141982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3535437..3536926
• Replicon: chromosome
• Accession: NZ_CP045492
• Organism: Mesorhizobium sp. NBSH29

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: GA830_RS17415
• Protein ID: WP_195163026.1
• Coordinates: 3535664..3536926 (+)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: GA830_RS17410
• Protein ID: WP_195163025.1
• Coordinates: 3535437..3535667 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA830_RS17390	3530475..3531235	+	761	Protein_3429	helix-turn-helix domain-containing protein	-
GA830_RS19870	3531232..3531714	+	483	WP_210330839.1	plasmid mobilization relaxosome protein MobC	-
GA830_RS17400	3531708..3533336	+	1629	WP_195163023.1	relaxase/mobilization nuclease domain-containing protein	-
GA830_RS17405	3533365..3535215	+	1851	WP_195163024.1	type IV secretory system conjugative DNA transfer family protein	-
GA830_RS17410	3535437..3535667	+	231	WP_195163025.1	type II toxin-antitoxin system Y4mF family antitoxin	Antitoxin
GA830_RS17415	3535664..3536926	+	1263	WP_195163026.1	type II toxin-antitoxin system HipA family toxin	Toxin
GA830_RS17420	3537119..3537514	+	396	WP_195163027.1	DUF2924 domain-containing protein	-
GA830_RS17425	3538013..3538231	+	219	WP_195163028.1	helix-turn-helix domain-containing protein	-
GA830_RS17430	3538242..3538508	+	267	WP_195163029.1	DNA-binding protein	-
GA830_RS17435	3538474..3539037	+	564	WP_195163030.1	hypothetical protein	-
GA830_RS17440	3539086..3539694	+	609	WP_195165023.1	tyrosine-type recombinase/integrase	-
GA830_RS17450	3539843..3540559	+	717	WP_195163031.1	SIMPL domain-containing protein	-
GA830_RS17455	3540651..3541061	-	411	WP_195163032.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 45744.47 Da
• Isoelectric Point: 5.3298

>T141982 WP_195163026.1 NZ_CP045492:3535664-3536926 [Mesorhizobium sp. NBSH29]
MTVRVLNVWWDGRIVGQFTQDRHGDIGFAYTEAWLDDEKALPLSASLPKRPTRFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPITAGPMKDQHQAPLDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKV
PLILIDGQLALPVSGQATTHILKPPIARFPGTTENEAFVMMLAAAIGLDVAPVEPRSANGRPFLLVERYDRYRDAEGLVR
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSERPSTDIAKLLDAVIFNLIVGNADAHGKNFSILYDDQGPRMA
PLYDLLSTVTYPDLSPKMAMRIGKRATLADMDADGWQAFSKETGVGLLLVRRRVKELTDATGDAIPRLSENMSPLAADSA
TLNHVAALIADRAKLAAMNI

Nucleotide

• Length: 1263 bp

>T141982 NZ_CP060271:c1818842-1818585 [Staphylococcus xylosus]
ATGGATGTAAAAGTAACAGTAATCGTAAGAGTATTAGGTTTAATTTTGGTGTTAGTGAATCAGTGGTTATCAAATAAAGG
TATTAGTCCTATTCCAGTTGATGAGTCAACATTAATGACAATAGCAGTAGCATTGCTTACGACATGGAAAGATAATCCAT
TTACTAGCGCTGCTAAAGAAAGTAATAAAATGATGAAAGAATTAAAAACCCAAAATAAGTATGAAAAAGTAGTGATGCGT
AATGGTAAAGAAGAGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8198.54 Da
• Isoelectric Point: 10.5957

>AT141982 WP_195163025.1 NZ_CP045492:3535437-3535667 [Mesorhizobium sp. NBSH29]
MAKQVRSPADIGTLVRSTRKEQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILAPGERRK

Nucleotide

• Length: 231 bp

>AT141982 NZ_CP060271:1818893-1819057 [Staphylococcus xylosus]
ATTTGATAATATTTTTATGTTGTGTTAATTTATATATAGAAAAAGGGCAATACACCATAAGTGTATCGCCCAAATGAGCC
CGTTAAAAAGACGGTGGCTAGTTACTAATAATTATCAAAAAATAATCATCGAAACCGGCCAAAGTTAGCGATGGTTATTT
TTTAT