Detailed information of TA system TA141981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3088344..3088957
• Replicon: chromosome
• Accession: NZ_CP045492
• Organism: Mesorhizobium sp. NBSH29

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GA830_RS15360
• Protein ID: WP_195162667.1
• Coordinates: 3088344..3088634 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GA830_RS15365
• Protein ID: WP_195162668.1
• Coordinates: 3088634..3088957 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA830_RS15340	3084521..3085912	-	1392	WP_195162663.1	glutathione-disulfide reductase	-
GA830_RS15345	3086041..3086673	-	633	WP_195162664.1	DUF2059 domain-containing protein	-
GA830_RS15350	3086680..3087390	-	711	WP_195162665.1	ribose-5-phosphate isomerase RpiA	-
GA830_RS15355	3087534..3088226	+	693	WP_195162666.1	phosphoglycolate phosphatase	-
GA830_RS15360	3088344..3088634	+	291	WP_195162667.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GA830_RS15365	3088634..3088957	+	324	WP_195162668.1	putative addiction module antidote protein	Antitoxin
GA830_RS15370	3089072..3089899	+	828	WP_195162669.1	hypothetical protein	-
GA830_RS15380	3090344..3092467	-	2124	WP_195162670.1	L,D-transpeptidase family protein	-
GA830_RS15385	3092689..3093435	-	747	WP_195162671.1	3-oxoacyl-ACP reductase FabG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10781.55 Da
• Isoelectric Point: 10.1358

>T141981 WP_195162667.1 NZ_CP045492:3088344-3088634 [Mesorhizobium sp. NBSH29]
MIEVRHSTVFSNWLKSLKDVRAQARIEIRIARVELGNLGDARFFDGIGELRIDYGPGYRVYLVKRGNTVVILLCGGDKSS
QKKDIKSAIAMAKELD

Nucleotide

• Length: 291 bp

>T141981 NZ_CP060271:c1812845-1812678 [Staphylococcus xylosus]
ATGTATGTAAAGGTAACAGTAATAGCAAGAGTATTAAGTTTGGTTTTGACGTTAGTTAACCAAAGGTTATCAAATAAAAG
TGTTAACCCTATTCTAGTTGATGAGTCAACGTTATTAACAATGGCAGAACCATTAAATACGACATGGAAAGATGATTCCA
ATAACTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11479.06 Da
• Isoelectric Point: 4.7119

>AT141981 WP_195162668.1 NZ_CP045492:3088634-3088957 [Mesorhizobium sp. NBSH29]
MAIETHKWDVTEYLDNEEAIFAYIEAAFEDGDPVLIKKALGEVARARGMTAMAKESGVTREALYKALSENGDPKLSTLLG
VAKALGVRLTIAPAATVSDYAEPRHGA

Nucleotide

• Length: 324 bp

>AT141981 NZ_CP060271:1812899-1813059 [Staphylococcus xylosus]
TTGATAATATATTTATGTTGTGTTAATTTATAGATAGAAAAAGGGCAACACACCATAAATGTATCGCCCTAATGAGCCCG
TTAAAAAGACGGTGACCATTCTTTAATGATTATCTTTAATAACCATCGAACCGGTCAAAGTTAGCGATGGTTATTTTTTA
T