Detailed information of TA system TA141980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 1864313..1864866
• Replicon: chromosome
• Accession: NZ_CP045492
• Organism: Mesorhizobium sp. NBSH29

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: GA830_RS09185
• Protein ID: WP_195161587.1
• Coordinates: 1864313..1864561 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: GA830_RS09190
• Protein ID: WP_195161588.1
• Coordinates: 1864558..1864866 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA830_RS09155	1859623..1859997	-	375	WP_195161582.1	type II toxin-antitoxin system VapC family toxin	-
GA830_RS09160	1859994..1860254	-	261	WP_195161583.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
GA830_RS09165	1860366..1861562	-	1197	WP_195161584.1	glycosyltransferase family 4 protein	-
GA830_RS09170	1862022..1863632	+	1611	WP_195161585.1	FAD-dependent oxidoreductase	-
GA830_RS09175	1863629..1863823	+	195	WP_195161586.1	DUF2783 domain-containing protein	-
GA830_RS09180	1863835..1864167	-	333	WP_195164868.1	ASCH domain-containing protein	-
GA830_RS09185	1864313..1864561	+	249	WP_195161587.1	BrnT family toxin	Toxin
GA830_RS09190	1864558..1864866	+	309	WP_195161588.1	BrnA antitoxin family protein	Antitoxin
GA830_RS09195	1864995..1866101	-	1107	WP_195161589.1	4-hydroxyphenylpyruvate dioxygenase	-
GA830_RS09200	1866218..1866685	+	468	WP_195161590.1	Lrp/AsnC family transcriptional regulator	-
GA830_RS09205	1866818..1867864	+	1047	WP_195161591.1	TRAP transporter substrate-binding protein	-
GA830_RS09210	1868027..1868551	+	525	WP_195161592.1	TRAP transporter small permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-78)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (26-99)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9199.90 Da
• Isoelectric Point: 8.8766

>T141980 WP_195161587.1 NZ_CP045492:1864313-1864561 [Mesorhizobium sp. NBSH29]
MKIVWDEPKRLANLAKHGLDFAVLDDLFFLDAIVQPARVGRFKAIGELEPGMVLAVIFHPMGSEGLSIISMRPARLSERR
LQ

Nucleotide

• Length: 249 bp

>T141980 NZ_CP045492:1864313-1864561 [Mesorhizobium sp. NBSH29]
ATGAAGATTGTGTGGGATGAGCCCAAACGGCTGGCCAATCTGGCAAAGCATGGCCTCGATTTTGCAGTGCTGGATGATTT
ATTCTTCCTCGATGCGATTGTGCAGCCAGCAAGAGTAGGCAGGTTCAAAGCGATTGGCGAACTGGAGCCGGGTATGGTGC
TGGCAGTCATCTTCCATCCAATGGGAAGCGAAGGGCTGTCAATTATCTCCATGCGCCCAGCAAGGCTTTCTGAAAGGCGT
TTGCAATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11705.15 Da
• Isoelectric Point: 8.5762

>AT141980 WP_195161588.1 NZ_CP045492:1864558-1864866 [Mesorhizobium sp. NBSH29]
MTKTKLKTEFEPGRGYIKQDWDAVSDNPEWTAEELRSAKPFAELFPEFADEIRRTRGRPVTDNPKKQVTLRLDSDVVARF
RADGPGWQSRINDVLRKAAGLD

Nucleotide

• Length: 309 bp

>AT141980 NZ_CP045492:1864558-1864866 [Mesorhizobium sp. NBSH29]
ATGACGAAGACTAAATTGAAAACTGAGTTTGAACCAGGTCGCGGCTACATTAAACAGGATTGGGACGCGGTTTCAGATAA
TCCAGAATGGACTGCTGAAGAACTTCGCAGTGCGAAACCGTTCGCTGAATTATTCCCCGAATTTGCTGATGAAATCCGCC
GCACGCGCGGTCGTCCCGTCACGGACAATCCCAAGAAGCAGGTGACATTGCGGCTCGACAGTGATGTCGTTGCCCGTTTT
CGCGCGGATGGTCCGGGCTGGCAAAGCCGTATCAATGATGTGCTGCGCAAGGCAGCCGGTTTAGACTAA