Detailed information of TA system TA141979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1010489..1011174
• Replicon: chromosome
• Accession: NZ_CP045492
• Organism: Mesorhizobium sp. NBSH29

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GA830_RS04930
• Protein ID: WP_195163984.1
• Coordinates: 1010489..1010911 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GA830_RS04935
• Protein ID: WP_195164776.1
• Coordinates: 1010908..1011174 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA830_RS04910	1006066..1007424	-	1359	WP_195164775.1	phosphonate ABC transporter, permease protein PhnE	-
GA830_RS04915	1007436..1008401	-	966	WP_195163981.1	phosphonate ABC transporter, permease protein PhnE	-
GA830_RS04920	1008463..1009374	-	912	WP_195163982.1	phosphonate ABC transporter substrate-binding protein	-
GA830_RS04925	1009449..1010294	-	846	WP_195163983.1	phosphonate ABC transporter ATP-binding protein	-
GA830_RS04930	1010489..1010911	-	423	WP_195163984.1	type II toxin-antitoxin system VapC family toxin	Toxin
GA830_RS04935	1010908..1011174	-	267	WP_195164776.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GA830_RS04940	1011257..1011871	-	615	WP_195163985.1	acetyltransferase	-
GA830_RS04945	1011868..1012575	-	708	WP_195163986.1	phosphonate C-P lyase system protein PhnL	-
GA830_RS04950	1012578..1013354	-	777	WP_195163987.1	phosphonate C-P lyase system protein PhnK	-
GA830_RS04955	1013351..1014241	-	891	WP_195163988.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
GA830_RS04960	1014238..1015341	-	1104	WP_195163989.1	carbon-phosphorus lyase complex subunit PhnI	-
GA830_RS04965	1015345..1015953	-	609	WP_195163990.1	phosphonate C-P lyase system protein PhnH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-70)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15595.04 Da
• Isoelectric Point: 5.2421

>T141979 WP_195163984.1 NZ_CP045492:c1010911-1010489 [Mesorhizobium sp. NBSH29]
VKLLLDTNILSEVTKPAPEPRVLEWLDSLDEDRCFISVVSIAEIRRGVALMDDGRKRGALADWLARDLPMRFEHRILPVN
EMVALAWGDLMGQAKQRGRGLSSMDGLIAATAFSNNLTLATRNIKDFDGFGLKLFDPWAA

Nucleotide

• Length: 423 bp

>T141979 NZ_CP060271:918149-918349 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGATATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACATAATGTTGCTATAGATATTGACAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9703.10 Da
• Isoelectric Point: 10.0862

>AT141979 WP_195164776.1 NZ_CP045492:c1011174-1010908 [Mesorhizobium sp. NBSH29]
MLSAPKDVTKWTVAGAKARLSEVIERAQSAPQTITRNGKPSVVVVSAEEWQRKTARKGTLAEFLLASPLRGTDLDITRLD
DEPRDFPL

Nucleotide

• Length: 267 bp

>AT141979 NZ_CP060271:917841-918134 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCGCATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGGCA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGGAAAAGGTCAACAA
GAAGAAGCAATGGAAGAATTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG