Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4933569..4934185 Replicon chromosome
Accession NZ_CP045487
Organism Enterobacter cloacae strain 14240244101

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GEA60_RS23395 Protein ID WP_080346008.1
Coordinates 4933569..4933940 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GEA60_RS23400 Protein ID WP_046889539.1
Coordinates 4933943..4934185 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA60_RS23380 4931069..4931971 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
GEA60_RS23385 4931968..4932603 + 636 WP_014833794.1 formate dehydrogenase cytochrome b556 subunit -
GEA60_RS23390 4932600..4933529 + 930 WP_203461701.1 formate dehydrogenase accessory protein FdhE -
GEA60_RS23395 4933569..4933940 - 372 WP_080346008.1 PIN domain-containing protein Toxin
GEA60_RS23400 4933943..4934185 - 243 WP_046889539.1 ribbon-helix-helix domain-containing protein Antitoxin
GEA60_RS23405 4934385..4935302 + 918 WP_203461702.1 alpha/beta hydrolase -
GEA60_RS23410 4935314..4936255 - 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
GEA60_RS23415 4936300..4936737 - 438 WP_014833798.1 D-tyrosyl-tRNA(Tyr) deacylase -
GEA60_RS23420 4936734..4937615 - 882 WP_014833799.1 virulence factor BrkB family protein -
GEA60_RS23425 4937609..4938208 - 600 WP_203461703.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.75 Da        Isoelectric Point: 6.6407

>T141978 WP_080346008.1 NZ_CP045487:c4933940-4933569 [Enterobacter cloacae]
MTNMAVFDTNILIDLFNNRVEAADAIDHAAAHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVVTPYQL

Download         Length: 372 bp

>T141978 NZ_CP060270:c264972-264637 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9413.69 Da        Isoelectric Point: 4.3224

>AT141978 WP_046889539.1 NZ_CP045487:c4934185-4933943 [Enterobacter cloacae]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRDALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp

>AT141978 NZ_CP060270:c265249-264962 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References