Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4071484..4072144 Replicon chromosome
Accession NZ_CP045487
Organism Enterobacter cloacae strain 14240244101

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9A2Z6
Locus tag GEA60_RS19275 Protein ID WP_014833181.1
Coordinates 4071484..4071897 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag GEA60_RS19280 Protein ID WP_013098615.1
Coordinates 4071878..4072144 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA60_RS19255 4067477..4069210 - 1734 WP_203461543.1 single-stranded-DNA-specific exonuclease RecJ -
GEA60_RS19260 4069216..4069929 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GEA60_RS19265 4069958..4070854 - 897 WP_203461544.1 site-specific tyrosine recombinase XerD -
GEA60_RS19270 4070956..4071477 + 522 WP_046889569.1 flavodoxin FldB -
GEA60_RS19275 4071484..4071897 - 414 WP_014833181.1 protein YgfX Toxin
GEA60_RS19280 4071878..4072144 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
GEA60_RS19285 4072439..4073419 + 981 WP_047361362.1 tRNA-modifying protein YgfZ -
GEA60_RS19290 4073529..4074188 - 660 WP_003863433.1 hemolysin III family protein -
GEA60_RS19295 4074454..4075185 + 732 WP_014833183.1 MurR/RpiR family transcriptional regulator -
GEA60_RS19300 4075302..4076735 + 1434 WP_047361360.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16206.14 Da        Isoelectric Point: 10.7596

>T141977 WP_014833181.1 NZ_CP045487:c4071897-4071484 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGQ
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRDLRRMILQQQPTQE

Download         Length: 414 bp

>T141977 NZ_CP060269:c264974-264639 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT141977 WP_013098615.1 NZ_CP045487:c4072144-4071878 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT141977 NZ_CP060269:c265251-264964 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9A2Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References