Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 3799557..3800290 Replicon chromosome
Accession NZ_CP045487
Organism Enterobacter cloacae strain 14240244101

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag GEA60_RS17990 Protein ID WP_043491403.1
Coordinates 3799961..3800290 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GEA60_RS17985 Protein ID WP_038416562.1
Coordinates 3799557..3799922 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA60_RS17935 3794816..3794965 + 150 WP_001458941.1 hypothetical protein -
GEA60_RS17940 3794977..3795192 + 216 WP_038416553.1 hypothetical protein -
GEA60_RS17945 3795337..3795747 + 411 WP_038416555.1 hypothetical protein -
GEA60_RS17950 3795813..3796751 + 939 WP_077887331.1 hypothetical protein -
GEA60_RS17955 3796825..3797058 + 234 WP_038416556.1 DUF905 domain-containing protein -
GEA60_RS17960 3797172..3797990 + 819 WP_171964800.1 DUF945 domain-containing protein -
GEA60_RS17965 3797990..3798244 + 255 WP_071881512.1 hypothetical protein -
GEA60_RS17970 3798341..3798808 + 468 WP_143829919.1 antirestriction protein -
GEA60_RS17975 3798819..3799298 + 480 WP_043491407.1 DNA repair protein RadC -
GEA60_RS17980 3799310..3799531 + 222 WP_038416561.1 DUF987 family protein -
GEA60_RS17985 3799557..3799922 + 366 WP_038416562.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GEA60_RS17990 3799961..3800290 + 330 WP_043491403.1 TA system toxin CbtA family protein Toxin
GEA60_RS17995 3800636..3801682 - 1047 WP_203461478.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
GEA60_RS18000 3801666..3802442 - 777 WP_203461479.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
GEA60_RS18005 3802581..3803366 - 786 WP_192544550.1 nucleotidyltransferase domain-containing protein -
GEA60_RS18010 3803672..3803998 + 327 WP_203461480.1 hypothetical protein -
GEA60_RS18015 3804012..3804827 - 816 WP_203461481.1 DUF4225 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3778014..3806637 28623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12384.08 Da        Isoelectric Point: 6.8692

>T141976 WP_043491403.1 NZ_CP045487:3799961-3800290 [Enterobacter cloacae]
MQTLSLHPTRATPLCLSPVETWQRLLAHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDREGF
SWQEQTPYISAVDILRARRSTGLLKTDVK

Download         Length: 330 bp

>T141976 NZ_CP060268:c258976-258641 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13509.23 Da        Isoelectric Point: 4.7952

>AT141976 WP_038416562.1 NZ_CP045487:3799557-3799922 [Enterobacter cloacae]
MNNHSESGTKPENPACKQWGLRCTITPCFGARLVQEGNRVHFLADRAGFNGAFSDEDVLRLDQAFSLILKQLELMLTSGE
LNPLYQHCVTLYHNGLTCEADTLGSFGYVYIAIYPDQPEPQ

Download         Length: 366 bp

>AT141976 NZ_CP060268:c259253-258966 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References