Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1137804..1138424 Replicon chromosome
Accession NZ_CP045487
Organism Enterobacter cloacae strain 14240244101

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag GEA60_RS05240 Protein ID WP_013095889.1
Coordinates 1137804..1138022 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag GEA60_RS05245 Protein ID WP_008499288.1
Coordinates 1138050..1138424 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA60_RS05210 1133816..1134076 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
GEA60_RS05215 1134079..1134219 + 141 WP_203461951.1 type B 50S ribosomal protein L36 -
GEA60_RS05220 1134216..1134926 - 711 WP_050860800.1 GNAT family N-acetyltransferase -
GEA60_RS05225 1135028..1136488 + 1461 WP_203461952.1 PLP-dependent aminotransferase family protein -
GEA60_RS05230 1136460..1136927 - 468 WP_013095887.1 membrane protein -
GEA60_RS05235 1137043..1137594 - 552 WP_014830901.1 maltose O-acetyltransferase -
GEA60_RS05240 1137804..1138022 - 219 WP_013095889.1 hemolysin expression modulator Hha Toxin
GEA60_RS05245 1138050..1138424 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
GEA60_RS05250 1138937..1142083 - 3147 WP_014830902.1 multidrug efflux RND transporter permease subunit -
GEA60_RS05255 1142106..1143299 - 1194 WP_014830903.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T141965 WP_013095889.1 NZ_CP045487:c1138022-1137804 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T141965 NZ_CP060263:1818823-1819137 [Dickeya zeae]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGTGCCATTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTAG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGTCGCCGACCGGATCGCCTTGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTCCAGGCTCTGGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGTGTTCAGGTAAAGGCCGCCATCGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT141965 WP_008499288.1 NZ_CP045487:c1138424-1138050 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT141965 NZ_CP060263:1818584-1818820 [Dickeya zeae]
ATGACCGTGAAACAACGCAACACGCAGAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAACTTCGCCACCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAGGCCATCGACGCATTAAACCGTTTTCATGATGAACGCAGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References