Detailed information of TA system TA141964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 520625..521141
• Replicon: chromosome
• Accession: NZ_CP045487
• Organism: Enterobacter cloacae strain 14240244101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GEA60_RS02485
• Protein ID: WP_083021762.1
• Coordinates: 520857..521141 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GEA60_RS02480
• Protein ID: WP_083021763.1
• Coordinates: 520625..520867 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEA60_RS02465	516656..517396	+	741	WP_014830446.1	KDGP aldolase family protein	-
GEA60_RS02470	517481..518617	+	1137	WP_050859680.1	lactonase family protein	-
GEA60_RS02475	518637..520547	+	1911	WP_203461810.1	BglG family transcription antiterminator	-
GEA60_RS02480	520625..520867	+	243	WP_083021763.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GEA60_RS02485	520857..521141	+	285	WP_083021762.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GEA60_RS02490	521145..521609	-	465	WP_203461811.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GEA60_RS02495	521727..523865	-	2139	WP_014830450.1	anaerobic ribonucleoside-triphosphate reductase	-
GEA60_RS02500	524239..525882	-	1644	WP_203461812.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10971.95 Da
• Isoelectric Point: 10.4251

>T141964 WP_083021762.1 NZ_CP045487:520857-521141 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFKKKLAGVLVNPRIESARLHNLPDCYKIKLRSLGYRLVYQVQDNVVTVVVIAIGK
REKLTVYHDANKRL

Nucleotide

• Length: 285 bp

>T141964 NZ_CP060263:1815372-1815686 [Dickeya zeae]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTGAATCGTCGGATCGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCTGCCGACCGGATCGCCTTGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTCCAGGCGCTGGGG
GCGGTATTTTGTGATGCGTCGCAGTACCGTAATCAGGTAAAGGCCGCCATTGATTTCCTTATTGACGGCATTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.40 Da
• Isoelectric Point: 5.0651

>AT141964 WP_083021763.1 NZ_CP045487:520625-520867 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDTLIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT141964 NZ_CP060263:1815133-1815369 [Dickeya zeae]
ATGACCGCGAAACAACGTAACACGCAGAGCGTGACCATGACGGTGGAGCGAGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGCGCCACCCTGACAACCGCTCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATTGACGCATTAAACCGTTTTCATGATGAACACGGCTGTTTCAGCGATGAATACAGGACCTTTTAA