Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 180749..181353 Replicon chromosome
Accession NZ_CP045487
Organism Enterobacter cloacae strain 14240244101

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag GEA60_RS00890 Protein ID WP_071843252.1
Coordinates 180749..180934 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5E1AFC9
Locus tag GEA60_RS00895 Protein ID WP_023621194.1
Coordinates 180949..181353 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA60_RS00875 177180..178718 + 1539 WP_203461752.1 aldehyde dehydrogenase -
GEA60_RS00880 178715..179680 - 966 WP_196372984.1 LysR family transcriptional regulator -
GEA60_RS00885 179798..180538 + 741 WP_063411373.1 MipA/OmpV family protein -
GEA60_RS00890 180749..180934 + 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
GEA60_RS00895 180949..181353 + 405 WP_023621194.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GEA60_RS00900 181407..183362 - 1956 WP_203461753.1 glycoside hydrolase family 127 protein -
GEA60_RS00905 183373..184773 - 1401 WP_196372986.1 MFS transporter -
GEA60_RS00910 184998..185816 + 819 WP_203461754.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T141963 WP_071843252.1 NZ_CP045487:180749-180934 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T141963 NZ_CP060263:c1681405-1681226 [Dickeya zeae]
ATGGACAGCAGGACGTTAATGGCAGAAATCAAGGCCGATGGATGGGAATTGGTAAGGATTAACGGCAGCCATCACCACTT
CATCCACCCAGCTAAACCGGGGTTAGTCACCATCCCGCATCCTAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGGATATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14888.72 Da        Isoelectric Point: 4.3036

>AT141963 WP_023621194.1 NZ_CP045487:180949-181353 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT141963 NZ_CP060263:c1681198-1680788 [Dickeya zeae]
ATGTTTTATCCAATTGCAATTGAAGCAGGCGACGATGCTCATGCATACGGCGTGACAGTGCCAGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACACTTGATGAGGCCATCGCCAACGCTAAAGACGCGATCACTGGTCACATTGAGCTGCTTATCGAAA
TGGGCCAGGCTATTCCTGCTGTTTCATCCGTCGGCACGTTGGCGAAATCACCAGAATACATCGGTTACACCTGGGCCGTT
GTTGATATCGATGTCACCCGGCTGATGGGGGGTGTGGAAAAAATTAACGTCACGCTGCCGAAATCACTGATTGACCGTAT
CGATCGTTGTGTAGCAAGTAACCCAGAATTTAAAAGCCGCTCGGGGTTCCTTGCCCAGGCGGCATTAGAGCGGATGTCAT
CCCTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFC9

References