Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3657061..3657718 Replicon chromosome
Accession NZ_CP045486
Organism Enterobacter cloacae strain 99101

Toxin (Protein)


Gene name cptA Uniprot ID A0A4V2LUM0
Locus tag GEA59_RS17280 Protein ID WP_063451987.1
Coordinates 3657061..3657471 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GEA59_RS17285 Protein ID WP_003863437.1
Coordinates 3657452..3657718 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA59_RS17260 3653059..3654792 - 1734 WP_203465131.1 single-stranded-DNA-specific exonuclease RecJ -
GEA59_RS17265 3654798..3655511 - 714 WP_063451984.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GEA59_RS17270 3655540..3656436 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
GEA59_RS17275 3656538..3657059 + 522 WP_063451986.1 flavodoxin FldB -
GEA59_RS17280 3657061..3657471 - 411 WP_063451987.1 protein YgfX Toxin
GEA59_RS17285 3657452..3657718 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GEA59_RS17290 3658012..3658992 + 981 WP_203465132.1 tRNA-modifying protein YgfZ -
GEA59_RS17295 3659077..3659736 - 660 WP_047729440.1 hemolysin III family protein -
GEA59_RS17300 3660003..3660734 + 732 WP_203466189.1 MurR/RpiR family transcriptional regulator -
GEA59_RS17305 3660851..3662284 + 1434 WP_203465133.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16277.13 Da        Isoelectric Point: 11.4775

>T141961 WP_063451987.1 NZ_CP045486:c3657471-3657061 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDAAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T141961 NZ_CP060263:c1112189-1111986 [Dickeya zeae]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCTGCAGACCATCGTCTGGCTGAGCTAACGATGAATAAAC
TTTACGACAAAGTGCCAACTGCCGTGTGGAAATACGTTCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT141961 WP_003863437.1 NZ_CP045486:c3657718-3657452 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT141961 NZ_CP060263:c1112611-1112243 [Dickeya zeae]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
AACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGTTGTGTGAGCGGGTTGAAAAATACCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATTCAGAGTTGCAGAAATGGAAAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCGTCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V2LUM0

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References