Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1146143..1146763 Replicon chromosome
Accession NZ_CP045486
Organism Enterobacter cloacae strain 99101

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag GEA59_RS05435 Protein ID WP_010428174.1
Coordinates 1146143..1146361 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GEA59_RS05440 Protein ID WP_006809850.1
Coordinates 1146389..1146763 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA59_RS05410 1142566..1144134 - 1569 WP_107534814.1 EAL domain-containing protein -
GEA59_RS05415 1144361..1144621 + 261 WP_063451670.1 type B 50S ribosomal protein L31 -
GEA59_RS05420 1144624..1144764 + 141 WP_063451669.1 type B 50S ribosomal protein L36 -
GEA59_RS05425 1144802..1145269 - 468 WP_063869025.1 hypothetical protein -
GEA59_RS05430 1145385..1145936 - 552 WP_203465743.1 maltose O-acetyltransferase -
GEA59_RS05435 1146143..1146361 - 219 WP_010428174.1 hemolysin expression modulator Hha Toxin
GEA59_RS05440 1146389..1146763 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GEA59_RS05445 1147273..1150419 - 3147 WP_063451666.1 multidrug efflux RND transporter permease subunit AcrB -
GEA59_RS05450 1150442..1151635 - 1194 WP_063451665.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T141950 WP_010428174.1 NZ_CP045486:c1146361-1146143 [Enterobacter cloacae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T141950 NZ_CP060244:1412039-1412527 [Entomobacter blattae]
GTGGGAGGAATGAGGCCTGTTCCGCTCAGTCCTCATCATGACCTGGAAGACTTCAACTCTGGGGATTTATCTCTTGATGA
ATGGCTCAGGAGAAAAGCTTTAAAAAATCAGGTAACAGGGGCTTTACGAACGTTTGTTTATTTGGAGAGTAATAGGGTTA
AGGGCTATTATGCTCTGGCATCAGGAGCTCTTGATCAGGCAGGAGCTCCGGGTTCAATTAGAAGAAATATGCCAGACCCT
ATTCCTGTGGCAGTTTTGGCTCGACTGGCTGTTGATAGCAGTTTACAGGGGCAAGGATTAGGGGCATCCCTTTTAAAGGA
TGTCGTGTTACGTCTCACTGAAGCAGCAGAGATAGTGGGTATTCGTGGAATACTGGTACACGCTGTTTCAGATCGGGCAA
AAAGTTTTTATAAGAAATATGGTTTTATTGATACAATAGGCGATCCCTACCGTTTGGTCTTTTCATTAAAGCAAAAACGT
CAAACCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT141950 WP_006809850.1 NZ_CP045486:c1146763-1146389 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT141950 NZ_CP060244:1411818-1412051 [Entomobacter blattae]
ATGCTTGAAGAAACGCGTCAATTAATTGATGCGGCAGCACAAATTACAGGAAAAACCAGAACGGAGTTTATAACAGAATC
ATCAAGGCGGTCTGCTGAAGATACGTTACTGGAGCAGACATATATAAGAGTTAGTCCAGAATCTTATGCGCATTTCCTGT
CTGTTCTTGATGAACCTCCTTCAGGAGAGGGGTATGAAAGACTTATGAAAGTTAAAACACCGTGGGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References