Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 53437..54098 Replicon chromosome
Accession NZ_CP045486
Organism Enterobacter cloacae strain 99101

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GEA59_RS00270 Protein ID WP_131637338.1
Coordinates 53700..54098 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GEA59_RS00265 Protein ID WP_131637336.1
Coordinates 53437..53703 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA59_RS00240 48653..49774 - 1122 WP_107534350.1 efflux RND transporter periplasmic adaptor subunit -
GEA59_RS00245 49922..50491 - 570 WP_022646570.1 TetR/AcrR family transcriptional regulator -
GEA59_RS00250 50677..51096 + 420 WP_203465430.1 GNAT family N-acetyltransferase -
GEA59_RS00255 51093..51740 - 648 WP_203465431.1 TetR/AcrR family transcriptional regulator -
GEA59_RS00260 51820..53319 + 1500 WP_203465432.1 MFS transporter -
GEA59_RS00265 53437..53703 + 267 WP_131637336.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GEA59_RS00270 53700..54098 + 399 WP_131637338.1 type II toxin-antitoxin system VapC family toxin Toxin
GEA59_RS00275 54288..55088 + 801 WP_063868677.1 lipoprotein NlpA -
GEA59_RS00280 55107..55787 - 681 WP_107534359.1 EAL domain-containing protein -
GEA59_RS00285 55863..56483 - 621 WP_063868682.1 response regulator transcription factor -
GEA59_RS00290 57059..57694 + 636 WP_193033092.1 DNA-binding response regulator -
GEA59_RS00295 57701..58765 - 1065 WP_193037630.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14525.66 Da        Isoelectric Point: 5.6052

>T141948 WP_131637338.1 NZ_CP045486:53700-54098 [Enterobacter cloacae]
MRHMLDTNIVSHLFKKHPEVVTRMAGLRPGEVCISSITEAELLYGADKKQNSELKETILSFLNTITICAWDSEAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLTVEDWTTAA

Download         Length: 399 bp

>T141948 NZ_CP060243:c6071740-6071462 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10246.52 Da        Isoelectric Point: 5.2080

>AT141948 WP_131637336.1 NZ_CP045486:53437-53703 [Enterobacter cloacae]
MERTAKLFKKGRHQAVVLPEEFAFETESVYIRRDEEGNVVLTPKAEQVKTWDNFFRLLENTNVPDSFLSKEERNQSVTKR
DPLDGVCS

Download         Length: 267 bp

>AT141948 NZ_CP060243:c6071450-6071145 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References