Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3623052..3623709 Replicon chromosome
Accession NZ_CP045485
Organism Enterobacter cloacae strain 88701

Toxin (Protein)


Gene name cptA Uniprot ID A0A4V2LUM0
Locus tag GEA56_RS17140 Protein ID WP_063451987.1
Coordinates 3623052..3623462 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GEA56_RS17145 Protein ID WP_003863437.1
Coordinates 3623443..3623709 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA56_RS17120 3619050..3620783 - 1734 WP_203463734.1 single-stranded-DNA-specific exonuclease RecJ -
GEA56_RS17125 3620789..3621502 - 714 WP_063451984.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GEA56_RS17130 3621531..3622427 - 897 WP_063451985.1 site-specific tyrosine recombinase XerD -
GEA56_RS17135 3622529..3623050 + 522 WP_063451986.1 flavodoxin FldB -
GEA56_RS17140 3623052..3623462 - 411 WP_063451987.1 protein YgfX Toxin
GEA56_RS17145 3623443..3623709 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GEA56_RS17150 3624003..3624983 + 981 WP_063451988.1 tRNA-modifying protein YgfZ -
GEA56_RS17155 3625093..3625752 - 660 WP_003863433.1 hemolysin III family protein -
GEA56_RS17160 3626019..3626750 + 732 WP_063451989.1 MurR/RpiR family transcriptional regulator -
GEA56_RS17165 3626867..3628300 + 1434 WP_063867889.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16277.13 Da        Isoelectric Point: 11.4775

>T141945 WP_063451987.1 NZ_CP045485:c3623462-3623052 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDAAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T141945 NZ_CP060243:c4918945-4918190 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT141945 WP_003863437.1 NZ_CP045485:c3623709-3623443 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT141945 NZ_CP060243:c4919448-4919080 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTGGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V2LUM0

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References